| MLB First Round Draft Picks - Houston Astros | ||||
| SEASON | PLAYER | POS | SCHOOL/HOMETOWN | PICK |
| 2016 | Forrest Whitley | RHP | Alamo Heights HS (San Antonio) | 17 |
| 2015 | Kyle Tucker | OF | Plant High School (Tampa) | 5 |
| 2015 | Alex Bregman | SS | LSU | 2 |
| 2014 | Brady Aiken | LHP | Cathedral Catholic HS, San Diego | 1 |
| 2013 | Mark Appel | RHP | Stanford | 1 |
| 2012 | Carlos Correa | SS | Puerto Rico Baseball Academy, Santa Isabel, | 1 |
| 2011 | George Springer | CF | Connecticut | 11 |
| 2010 | Michael Kvasnicka | C | Minnesota | 33 |
| 2010 | Mike Foltynewicz | RHP | Minooka (Ill.) HS | 19 |
| 2010 | Delino DeShields Jr. | CF | Woodward Academy, College Park, Ga. | 8 |
| 2009 | Jiovanni Mier | SS | Bonita HS, La Verne, Calif. | 21 |
| 2008 | Jason Castro | C | Stanford | 10 |
| 2006 | Maxwell Sapp | C | Bishop Moore School (Orlando, Fla) | 23 |
| 2005 | Brian Bogusevic | LHP | Tulane | 24 |
| 2002 | Derick Grigsby | RHP | Northeast Texas CC | 29 |
| 2001 | Chris Burke | SS | U. of Tennessee | 10 |
| 2000 | Robert Stiehl | C | Torrance, CA | 27 |
| 1998 | Brad Lidge | RHP | U. of Notre Dame | 17 |
| 1997 | Lance Berkman | 1B | Rice U | 16 |
| 1996 | Mark Johnson | RHP | U of Hawaii | 19 |
| 1995 | Tony McKnight | RHP | Texarkana, AR | 22 |
| 1994 | Scott Elarton | RHP | Lamar, CO | 25 |
| 1994 | Ramon Castro | C | Vega Baja, PR | 17 |
| 1993 | Billy Wagner | LHP | Ferrum College | 12 |
| 1992 | Phil Nevin | 3B | Cal State Fullerton | 1 |
| 1991 | John Burke | RHP | U of Florida | 6 |
| 1990 | Thomas Nevers | SS | Edina, MN | 21 |
| 1989 | Jeff Juden | RHP | Salem, MA | 12 |
| 1988 | Willie Ansley | OF | Plainview, TX | 7 |
| 1987 | Craig Biggio | C | Seton Hall U | 22 |
| 1986 | Ryan Bowen | RHP | Hanford, CA | 13 |
| 1985 | Cameron Drew | OF | U of New Haven | 12 |
| 1984 | Don August | RHP | Chapman College | 17 |
| 1983 | Robbie Wine | C | Oklahoma State U | 8 |
| 1982 | Steve Swain | OF | El Cajon, CA | 15 |
| 1979 | John Mizerock | C | Punxsutawney, PA | 8 |
| 1978 | Rod Boxberger | RHP | U of Southern California | 11 |
| 1977 | Ricky Adams | SS | Montclair, CA | 14 |
| 1976 | Floyd Bannister | LHP | Arizona State U | 1 |
| 1975 | Bo McLaughlin | RHP | David Lipscomb Col. | 14 |
| 1974 | Kevin Drake | OF | Lompoc, CA | 15 |
| 1973 | Calvin Portley | SS | Longview, TX | 20 |
| 1972 | Steve Englishbey | OF | Houston, TX | 9 |
| 1971 | Neil Rasmussen | SS | Arcadia, CA | 12 |
| 1970 | *-Randy Scarbery | RHP | Fresno, CA | 7 |
| 1969 | J.R. Richard | RHP | Ruston, LA | 2 |
| 1968 | Marty Cott | C | Buffalo, NY | 3 |
| 1967 | John Mayberry | 1B | Detroit, MI | 6 |
| 1966 | Wayne Twitchell | RHP | Portland, OR | 3 |
| 1965 | Alex Barrett | SS | Winton, CA | 4 |