| MLB First Round Draft Picks - 1966 | ||||
| PICK | PLAYER | POS | TEAM | SCHOOL/HOMETOWN |
| 1 | Steve Chilcott | C | New York Mets | Lancaster, CA |
| 2 | Reggie Jackson | OF | Kansas City Athletics | Arizona State U |
| 3 | Wayne Twitchell | RHP | Houston Astros | Portland, OR |
| 4 | Ken Brett | LHP | Boston Red Sox | El Segundo, CA |
| 5 | Dean Burk | RHP | Chicago Cubs | Highland, IL |
| 6 | Tom Grieve | OF | Washington Senators | Pittsfield, MA |
| 7 | Leron Lee | OF | St. Louis Cardinals | Sacramento, CA |
| 8 | Jim DeNeff | SS | California Angels | Indiana U |
| 9 | Mike Biko | RHP | Philadelphia Phillies | Dallas, TX |
| 10 | Jim Lyttle | OF | New York Yankees | Florida State U |
| 11 | Al Santorini | RHP | Atlanta Braves | Union, NJ |
| 12 | *-John Curtis | LHP | Cleveland Indians | Smithtown, NY |
| 13 | Gary Nolan | RHP | Cincinnati Reds | Oroville, CA |
| 14 | *-Rick Konik | 1B | Detroit Tigers | Detroit, MI |
| 15 | Richie Hebner | SS | Pittsburgh Pirates | Norwood, MA |
| 16 | Ted Parks | SS | Baltimore Orioles | U of California |
| 17 | Bob Reynolds | RHP | San Francisco Giants | Seattle, WA |
| 18 | Carlos May | OF | Chicago White Sox | Birmingham, AL |
| 19 | Larry Hutton | RHP | Los Angeles Dodgers | Greenfield, IN |
| 20 | Bob Jones | 3B | Minnesota Twins | Dawson, GA |