| MLB First Round Draft Picks - Cleveland Guardians | ||||
| SEASON | PLAYER | POS | SCHOOL/HOMETOWN | PICK |
| 2016 | Will Benson | OF | The Westminster Schools (Atlanta) | 14 |
| 2015 | Brady Aiken | LHP | IMG Academy (Bradenton, Fla.) | 17 |
| 2014 | Bradley Zimmer | OF | San Francisco | 21 |
| 2013 | Clint Frazier | OF | Loganville (Ga.) High School | 5 |
| 2012 | Tyler Naquin | OF | Texas A&M | 15 |
| 2011 | Francisco Lindor | SS | Monteverde Academy | 8 |
| 2010 | Drew Pomeranz | LHP | Mississippi | 5 |
| 2009 | Alex White | RHP | North Carolina | 15 |
| 2008 | Lonnie Chisenhall | 3B | Pitt CC, Greenville, N.C. | 29 |
| 2007 | Beau Mills | 3B | Lewis-Clark State | 13 |
| 2005 | Trevor Crowe | CF | Arizona | 14 |
| 2004 | Jeremy Sowers | LHP | Vanderbilt | 6 |
| 2003 | Bradley Snyder | OF | Ball State U. | 18 |
| 2003 | Michael Aubrey | 1B | Tulane U. | 11 |
| 2002 | Jeremy Guthrie | RHP | Stanford | 22 |
| 2001 | Alan Horne | RHP | Marianna (Fla.) HS | 27 |
| 2001 | Dan Denham | RHP | Deer Valley HS, Antioch, | 17 |
| 2000 | Corey Smith | SS | Piscataway, NJ | 26 |
| 1998 | Carsten Sabathia | LHP | Vallejo, CA | 20 |
| 1997 | Tim Drew | RHP | Hahira, GA | 28 |
| 1996 | Danny Peoples | 1B | U of Texas | 28 |
| 1995 | David Miller | 1B | Clemson U | 23 |
| 1994 | Jaret Wright | RHP | Anaheim, CA | 10 |
| 1993 | Daron Kirkreit | RHP | U of Cal-Riverside | 11 |
| 1992 | Paul Shuey | RHP | U of North Carolina | 2 |
| 1991 | Manuel Ramirez | OF | New York, NY | 13 |
| 1990 | Timothy Costo | SS | U of Iowa | 8 |
| 1989 | *-Calvin Murray | 3B | Dallas, TX | 11 |
| 1988 | Charles Nagy | RHP | U of Connecticut | 17 |
| 1988 | Mark Lewis | SS | Hamilton, OH | 2 |
| 1986 | Greg Swindell | LHP | U of Texas | 2 |
| 1985 | Mike Poehl | RHP | U of Texas | 9 |
| 1984 | Cory Snyder | SS | Brigham Young U | 4 |
| 1983 | Dave Clark | OF | Jackson State U | 11 |
| 1982 | Mark Snyder | RHP | Knoxville, TN | 12 |
| 1981 | George Alpert | OF | Livingston, NJ | 13 |
| 1980 | Kelly Gruber | SS | Austin, TX | 10 |
| 1979 | Jon Bohnet | LHP | Vallejo, CA | 7 |
| 1978 | Phil Lansford | SS | Santa Clara, CA | 10 |
| 1977 | Bruce Compton | OF | Norman, OK | 11 |
| 1976 | Tim Glass | C | Springfield, OH | 14 |
| 1975 | Rick Cerone | C | Seton Hall U | 7 |
| 1974 | Tom Brennan | RHP | Lewis U | 4 |
| 1973 | Glenn Tufts | 1B | Bridgewater, MA | 5 |
| 1972 | Rick Manning | SS | Niagara Falls, NY | 2 |
| 1971 | David Sloan | RHP | Santa Clara, CA | 9 |
| 1970 | Steve Dunning | RHP | Stanford U | 2 |
| 1969 | Alvin McGrew | OF | Fairfield, AL | 15 |
| 1968 | Robert Weaver | SS | Jacksonville, FL | 6 |
| 1967 | Jack Heidemann | SS | Brenham, TX | 11 |
| 1966 | *-John Curtis | LHP | Smithtown, NY | 12 |
| 1965 | Ray Fosse | C | Marion, IL | 7 |