| MLB First Round Draft Picks - 1991 | ||||
| PICK | PLAYER | POS | TEAM | SCHOOL/HOMETOWN |
| 1 | Brien Taylor | LHP | New York Yankees | Beaufort, NC |
| 2 | Mike Kelly | OF | Atlanta Braves | Arizona State U |
| 3 | David McCarty | OF | Minnesota Twins | Stanford U |
| 4 | Dmitri Young | SS | St. Louis Cardinals | Camarillo, CA |
| 5 | James Henderson | RHP | Milwaukee Brewers | Ringgold, GA |
| 6 | John Burke | RHP | Houston Astros | U of Florida |
| 7 | Joseph Vitiello | OF | Kansas City Royals | U of Alabama |
| 8 | Johns Hamilton | RHP | San Diego Padres | Georgia Southern U |
| 9 | Mark Smith | OF | Baltimore Orioles | U of Southern California |
| 10 | Tyler Green | RHP | Philadelphia Phillies | Wichita State U |
| 11 | Aaron Estes | LHP | Seattle Mariners | Gardnerville, NV |
| 12 | Douglas Glanville | OF | Chicago Cubs | U of Pennsylvania |
| 13 | Manuel Ramirez | OF | Cleveland Indians | New York, NY |
| 14 | Cornelius Floyd | 1B | Montreal Expos | Markham, IL |
| 15 | Tyrone Hill | LHP | Milwaukee Brewers | Yucaipa, CA |
| 16 | Shawn Green | OF | Toronto Blue Jays | Santa Ana, CA |
| 17 | Eduardo Perez | 1B | California Angels | Florida State U |
| 18 | Alfred Shirley | OF | New York Mets | George Washington U |
| 19 | Benjamin Gil | SS | Texas Rangers | San Diego, CA |
| 20 | Calvin Reese | SS | Cincinnati Reds | Columbia, SC |
| 21 | Allen Watson | LHP | St. Louis Cardinals | New York Institute |
| 22 | Brian Barber | RHP | St. Louis Cardinals | Orlando, FL |
| 23 | Aaron Sele | RHP | Boston Red Sox | Washington State U |
| 24 | Jonathan Farrell | OF | Pittsburgh Pirates | Florida CC |
| 25 | Scott Ruffcorn | RHP | Chicago White Sox | Baylor U |
| 26 | Brent Gates | SS | Oakland Athletics | U of Minnesota |