| MLB First Round Draft Picks - 2010 | ||||
| PICK | PLAYER | POS | TEAM | SCHOOL/HOMETOWN |
| 1 | Bryce Harper | C | Washington Nationals | College of Southern Nevada |
| 2 | Jameson Taillon | RHP | Pittsburgh Pirates | The Woodlands (Texas) HS |
| 3 | Manny Machado | SS | Baltimore Orioles | Brito Private, Miami, Fla. |
| 4 | Christian Colon | SS | Kansas City Royals | Cal State Fullerton |
| 5 | Drew Pomeranz | LHP | Cleveland Indians | Mississippi |
| 6 | Barret Loux | RHP | Arizona Diamondbacks | Texas A&M |
| 7 | Matt Harvey | RHP | New York Mets | North Carolina |
| 8 | Delino DeShields Jr. | CF | Houston Astros | Woodward Academy, College Park, Ga. |
| 9 | Karsten Whitson | RHP | San Diego Padres | Chipley (Fla.) HS |
| 10 | Michael Choice | CF | Oakland Athletics | Texas Arlington |
| 11 | Deck McGuire | RHP | Toronto Blue Jays | Georgia Tech |
| 12 | Yasmani Grandal | C | Cincinnati Reds | Miami |
| 13 | Chris Sale | LHP | Chicago White Sox | Florida Gulf Coast University |
| 14 | Dylan Covey | RHP | Milwaukee Brewers | Maranatha HS, Pasadena, Calif. |
| 15 | Jake Skole | OF | Texas Rangers | Blessed Trinity HS, Woodstock, Ga. |
| 16 | Hayden Simpson | RHP | Chicago Cubs | Southern Arkansas |
| 17 | Josh Sale | RF | Tampa Bay Rays | Bishop Blanchet HS, Seattle, Wash. |
| 18 | Kaleb Cowart | SS | Los Angeles Angels | Cook County HS, Adel, Ga. |
| 19 | Mike Foltynewicz | RHP | Houston Astros | Minooka (Ill.) HS |
| 20 | Kolbrin Vitek | 2B | Boston Red Sox | Ball State |
| 21 | Alex Wimmers | RHP | Minnesota Twins | Ohio State |
| 22 | Kellin Deglan | C | Texas Rangers | Langley High School, British Columbia |
| 23 | Christian Yelich | 1B | Florida Marlins | Westlake (Calif.) HS |
| 24 | Gary Brown | CF | San Francisco Giants | Cal State Fullerton |
| 25 | Zack Cox | 3B | St. Louis Cardinals | Arkansas |
| 26 | Kyle Parker | 1B | Colorado Rockies | Clemson |
| 27 | Jesse Biddle | LHP | Philadelphia Phillies | Germantown HS, Philadelphia, Penn. |
| 28 | Zach Lee | RHP | Los Angeles Dodgers | McKinney (Texas) HS |
| 29 | Cam Bedrosian | RHP | Los Angeles Angels | East Coweta High School, Sharpsburg, Ga. |
| 30 | Chevez Clarke | OF | Los Angeles Angels | Marietta (Ga.) High School |
| 31 | Justin O'Conner | C | Tampa Bay Rays | Cowan HS, Muncie, Ind. |
| 32 | Cito Culver | SS | New York Yankees | Irondequoit HS, Rochester, N.Y. |
| 33 | Michael Kvasnicka | C | Houston Astros | Minnesota |
| 34 | Aaron Sanchez | RHP | Toronto Blue Jays | Barstow (Calif.) High School |
| 35 | Matt Lipka | SS | Atlanta Braves | McKinney (Texas) HS |
| 36 | Bryce Brentz | OF | Boston Red Sox | Middle Tennessee State |
| 37 | Taylor Lindsey | SS | Los Angeles Angels | Desert Mountain HS, Scottsdale, Ariz. |
| 39 | Anthony Ranaudo | RHP | Boston Red Sox | Louisiana State University |
| 41 | Asher Wojciechowski | RHP | Toronto Blue Jays | The Citadel |
| 42 | Drew Vettleson | OF | Tampa Bay Rays | Central Kitsap HS, Silverdale, Wash. |
| 43 | Taijuan Walker | RHP | Seattle Mariners | Yucaipa (Calif.) High School |
| 44 | Nick Castellanos | 3B | Detroit Tigers | Archbishop McCarthy HS, Fort Lauderdale, Fla. |
| 45 | Luke Jackson | RHP | Texas Rangers | Calvary Christian, Fort Lauderdale, Fla. |
| 46 | Seth Blair | RHP | St. Louis Cardinals | Arizona State |
| 47 | Peter Tago | RHP | Colorado Rockies | Dana Hills High School, Dana Point, Calif. |
| 48 | Chance Ruffin | RHP | Detroit Tigers | Texas |
| 50 | Tyrell Jenkins | RHP | St. Louis Cardinals | Henderson (Tex.) High School |