| MLB First Round Draft Picks - 1988 | ||||
| PICK | PLAYER | POS | TEAM | SCHOOL/HOMETOWN |
| 1 | Andy Benes | RHP | San Diego Padres | U of Evansville |
| 2 | Mark Lewis | SS | Cleveland Indians | Hamilton, OH |
| 3 | Steve Avery | LHP | Atlanta Braves | Taylor, MI |
| 4 | Gregg Olson | RHP | Baltimore Orioles | Auburn U |
| 5 | Bill Bene | RHP | Los Angeles Dodgers | Cal State - LA |
| 6 | Monty Fariss | SS | Texas Rangers | Oklahoma State U |
| 7 | Willie Ansley | OF | Houston Astros | Plainview, TX |
| 8 | Jim Abbott | LHP | California Angels | U of Michigan |
| 9 | Ty Griffin | 2B | Chicago Cubs | Georgia Tech |
| 10 | Robin Ventura | 3B | Chicago White Sox | Oklahoma State U |
| 11 | Pat Combs | LHP | Philadelphia Phillies | Baylor U |
| 12 | Tom Fischer | LHP | Boston Red Sox | U of Wisconsin |
| 13 | Austin Manahan | SS | Pittsburgh Pirates | Phoenix, AZ |
| 14 | Tino Martinez | 1B | Seattle Mariners | U of Tampa |
| 15 | Royce Clayton | SS | San Francisco Giants | Playa del Rey, CA |
| 16 | Stan Royer | 3B | Oakland Athletics | Eastern Illinois U |
| 17 | Charles Nagy | RHP | Cleveland Indians | U of Connecticut |
| 18 | Hugh Walker | OF | Kansas City Royals | Jacksonville, AR |
| 19 | David Wainhouse | RHP | Montreal Expos | Washington State U |
| 20 | Johnny Ard | RHP | Minnesota Twins | Manatee JC |
| 21 | Dave Proctor | RHP | New York Mets | Allen County CC |
| 22 | John Ericks | RHP | St. Louis Cardinals | U of Illinois |
| 23 | Brad DuVall | RHP | St. Louis Cardinals | Virginia Tech |
| 24 | *-Alex Fernandez | RHP | Milwaukee Brewers | Miami, FL |
| 25 | Ed Sprague | 3B | Toronto Blue Jays | Stanford U |
| 26 | Rico Brogna | 1B | Detroit Tigers | Watertown, CT |