| MLB First Round Draft Picks - 2016 | ||||
| PICK | PLAYER | POS | TEAM | SCHOOL/HOMETOWN |
| 1 | Mickey Moniak | OF | Philadelphia Phillies | La Costa Canyon HS (Carlsbad, California) |
| 2 | Nick Senzel | 3B | Cincinnati Reds | Tennessee |
| 3 | Ian Anderson | RHP | Atlanta Braves | Shenendehowa HS (Clifton Park, New York) |
| 4 | Riley Pint | RHP | Colorado Rockies | St. Thomas Aquinas HS (Overland Park, Kansas) |
| 5 | Corey Ray | OF | Milwaukee Brewers | Louisville |
| 6 | A.J. Puk | LHP | Oakland Athletics | Florida |
| 7 | Braxton Garrett | LHP | Miami Marlins | Florence (Alabama) High School |
| 8 | Cal Quantrill | RHP | San Diego Padres | Stanford |
| 9 | Matt Manning | RHP | Detroit Tigers | Sheldon High School (Sacramento) |
| 10 | Zack Collins | C | Chicago White Sox | Miami |
| 11 | Kyle Lewis | OF | Seattle Mariners | Mercer |
| 12 | Jason Groome | LHP | Boston Red Sox | Barnegat (New Jersey) High School |
| 13 | Josh Lowe | 3B | Tampa Bay Rays | Pope High School (Marietta, Georgia) |
| 14 | Will Benson | OF | Cleveland Indians | The Westminster Schools (Atlanta) |
| 15 | Alex Kirilloff | OF | Minnesota Twins | Plum High School (Pittsburgh) |
| 16 | Matt Thaiss | C | Los Angeles Angels | Virginia |
| 17 | Forrest Whitley | RHP | Houston Astros | Alamo Heights HS (San Antonio) |
| 18 | Blake Rutherford | OF | New York Yankees | Chaminade College Prep (West Hills, Calif.) |
| 19 | Justin Dunn | RHP | New York Mets | Boston College |
| 20 | Gavin Lux | SS | Los Angeles Dodgers | Indian Trail Academy (Kenosha, Wisconsin) |
| 21 | T.J. Zeuch | RHP | Toronto Blue Jays | Pittsburgh |
| 22 | Will Craig | 1B | Pittsburgh Pirates | Wake Forest |
| 23 | Delvin Perez | SS | St. Louis Cardinals | International Baseball Academy (Puerto Rico) |
| 24 | Hudson Sanchez | 3B | San Diego Padres | Southlake (Texas) Carroll High School |
| 25 | Eric Lauer | LHP | San Diego Padres | Kent State |
| 26 | Zack Burdi | RHP | Chicago White Sox | Louisville |
| 27 | Cody Sedlock | RHP | Baltimore Orioles | Illinois |
| 28 | Carter Kieboom | 3B | Washington Nationals | Walton High School (Marietta, Georgia) |
| 29 | Dane Dunning | RHP | Washington Nationals | Florida |
| 30 | Cole Ragans | LHP | Texas Rangers | North Florida Christian (Tallahassee, Fla.) |
| 31 | Anthony Kay | LHP | New York Mets | Connecticut |
| 32 | Will Smith | C | Los Angeles Dodgers | Louisville |
| 33 | Dylan Carlson | 1B | St. Louis Cardinals | Elk Grove (California) HS |
| 34 | Dakota Hudson | RHP | St. Louis Cardinals | Mississippi State |