San Francisco 49ers @ Buffalo Bills
Game Leaders
Team Stats
377
Total Yards
352
4
Turnovers
0
23
1st Downs
21
22-178
Penalties
12-106
6/13
3rd Down
4/14
0/0
4th Down
0/1
0/0
Red Zone
0/0
27:07
Possession
32:53
Game Information
Referee:Dick Hantak
Team Stats
| 1st Downs | 23 | 21 |
| Passing 1st downs | 14 | 9 |
| Rushing 1st downs | 4 | 5 |
| 1st downs from penalties | 5 | 7 |
| 3rd down efficiency | 6-13 | 4-14 |
| 4th down efficiency | 0-0 | 0-1 |
| Total Plays | 61 | 68 |
| Total Yards | 377 | 352 |
| Total Drives | 0 | 0 |
| Yards per Play | 6.2 | 5.2 |
| Passing | 312 | 237 |
| Comp/Att | 23/38 | 19/27 |
| Yards per pass | 7.3 | 7.9 |
| Interceptions thrown | 1 | 0 |
| Sacks-Yards Lost | 5-17 | 3-17 |
| Rushing | 65 | 115 |
| Rushing Attempts | 18 | 38 |
| Yards per rush | 3.6 | 3.0 |
| Red Zone (Made-Att) | 0-0 | 0-0 |
| Penalties | 22-178 | 12-106 |
| Turnovers | 4 | 0 |
| Fumbles lost | 3 | 0 |
| Interceptions thrown | 1 | 0 |
| Defensive / Special Teams TDs | 0 | 0 |
| Possession | 27:07 | 32:53 |
2025 Standings
National Football Conference
| NFC West | W | L | T | PCT | PF | PA |
|---|---|---|---|---|---|---|
| Seattle | 14 | 3 | 0 | .824 | 483 | 292 |
| Los Angeles | 12 | 5 | 0 | .706 | 518 | 346 |
| San Francisco | 12 | 5 | 0 | .706 | 437 | 371 |
| Arizona | 3 | 14 | 0 | .176 | 355 | 488 |
American Football Conference
| AFC East | W | L | T | PCT | PF | PA |
|---|---|---|---|---|---|---|
| New England | 14 | 3 | 0 | .824 | 490 | 320 |
| Buffalo | 12 | 5 | 0 | .706 | 481 | 365 |
| Miami | 7 | 10 | 0 | .412 | 347 | 424 |
| New York | 3 | 14 | 0 | .176 | 300 | 503 |
NFL News

KC Concepcion to Eisen: ‘I want to be a Hall of Famer’
KC Concepcion joins “The Rich Eisen Show” and details his career goals ahead of the NFL draft.
41m

Sources: Odell Beckham Jr. works out for Giants, takes physical
The Giants had free agent wide receiver Odell Beckham Jr. in for a workout and physical with the team Monday, sources told ESPN.
7m

NFL fifth-year option tracker: 2023 first-round draft class
The deadline for teams to pick up the fifth-year option on rookie contracts is May 1. Which players have had their options picked up?
11m
GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). Terms: sportsbook.draftkings.com/promos.
Copyright: © 2026 ESPN Enterprises, LLC. All rights reserved.







