The shock defeat was the final straw for the Glazer family, as the United owners confirmed Solskjaer's exit after a wretched run of five defeats in seven Premier League games.
Former assistant Michael Carrick will take charge before the club appoint an interim manager until the end of the season.
Here's how social media reacted to Solskjaer's exit.
Former United defender and now pundit Gary Neville reminded people that Solskjaer initially did well, while some of the current side also showed their support.
Thank you Ole. You did us proud . The last two months were tough but before that you restored some soul into the club. ❤️ pic.twitter.com/cseYVIFgqK— Gary Neville (@GNev2) November 21, 2021
Club legend ♥️ pic.twitter.com/Dhef4U0T2A— Marcus Rashford MBE (@MarcusRashford) November 21, 2021
You signed me for the best club in the world and gave me the biggest honour in football. Huge respect and forever grateful.— Harry Maguire (@HarryMaguire93) November 21, 2021
Thankyou for everything boss.
Legend 🔴 pic.twitter.com/coBoYmEvFv
But things went south, as the stats prove.
21 - Through 12 games of the Premier League season, Manchester United have conceded 21 goals; they've never previously conceded more at this stage of a season in the competition. Wheel. pic.twitter.com/YleGFnzYuI— OptaJoe (@OptaJoe) November 21, 2021
Ole Gunnar Solskjaer remains the highest scoring PL player to have all the letters in Goal in his name. You can't sack that.— Duncan Alexander (@oilysailor) November 21, 2021
Some questioned how the transition to Carrick, who was part of Solskjaer's coaching staff, before an interim manager is appointed will go.
Congratulations to Michael Carrick on being appointed assistant *to* the regional manager pic.twitter.com/ggHGUmcqqy— Tom Williams (@tomwfootball) November 21, 2021
Man Utd started assessing options seriously after the Liverpool defeat. So to be unable to identify an interim, let alone a manager, in over a month is a remarkable development— Mark Ogden (@MarkOgden_) November 21, 2021
Carrick and *then* an interim manager.— Jonathan Fadugba (@JFfutbol) November 21, 2021
This club is beyond saving.
And perhaps there is one player who might not be all that unhappy to see the back of Solskjaer.
The last goal of the Solskjaer era was scored by Donny van de Beek. pic.twitter.com/BMaN7YeBjI— ESPN FC (@ESPNFC) November 21, 2021
Remember when Ole was at the wheel? Or, for that matter, when Jose Mourinho was?
FOR SALE: Wheel. Hardly used. One previous owner. Collection from Trafford area only.— Jonny Sharples (@JonnyGabriel) November 21, 2021
Eight-and-a-half years on, Mourinho - ignored in 2013 for Moyes (!) and not backed six months after he signed a new contract in 2018 - remains by far and away #mufc's most successful manager post-Ferguson.— Samuel Luckhurst (@samuelluckhurst) November 21, 2021
Eight years after Sir Alex Ferguson retired, Manchester United still haven't found the one 🙃 pic.twitter.com/CntooUglq7— B/R Football (@brfootball) November 21, 2021
So who could be next to take over as permanent manager? Or at least permanent interim manager?
Roy Keane as interim #MUFC boss is what we all want, isn't it?— Ian Doyle (@IanDoyleSport) November 21, 2021
An experienced interim manager until the end of the season. Have people started linking United with Arsene Wenger yet?— Si Lloyd (@SmnLlyd5) November 21, 2021
Con las limitadas opciones que tiene el United para reemplazar a Ole en el banquillo, esta podría ser la mejor 😅 pic.twitter.com/kqFgIqUPen— 90min ES (@90minEspanol) November 21, 2021