Three years since they last defended the Quad Series, the Australian Diamonds will face England, New Zealand and South Africa for their sixth title in January.
Across a four-day tournament in London, the Diamonds will go head-to-head once, with a third and fourth place game and a final to decide the winner of the Quad Series trophy.
Six years since the launch of the series in 2016, the Diamonds have won five of the six tournaments and new coach Stacey Marinkovich is determined to add her first trophy to her coaching career.
"I am incredibly excited to see how we transfer what we worked on during the recent performance camp to the international stage," Marinkovich said.
"This is a fantastic opportunity to test ourselves as we lead into an important year with the Commonwealth Games."
2022 Netball Quad Series fixture (AEDT)
New Zealand vs Australia Diamonds, 16 January at 3:15am
Australia Diamonds vs South Africa: 17 January at 1:00am
England vs Origin Diamonds: 19 January at 6:30am
3 vs 4: 20 January at 4:30am
Final: 1 vs 2: 20 January at 6:30am