GREENVILLE, N.C. -- Gardner Minshew threw for a career-high 444 yards and four touchdowns, Trevon Brown accounted for a school record 270 yards receiving and two touchdowns and East Carolina handled Cincinnati 48-20 on Saturday.

Minshew's 444 yards is the fifth-highest yardage total for a single game in East Carolina (3-8, 2-5 American Athletic) history. Minshew threw a 23-yard touchdown to Tahj Deans, Hussein Howe ran it in from 3-yards out and Minshew threw a 1-yarder to Jimmy Williams and the Pirates built a 21-0 lead with 9:06 left before halftime.

Hayden Moore responded on the following drive with a 75-yard touchdown pass to Kahlil Lewis to make it 21-6 after missing the point after, and Moore later threw a 10-yard score to JaQuay Savage to shave the deficit to 21-13.

Following a Pirates field goal just before halftime, Minshew threw a 95-yard score to Brown -- the longest in school history -- and a 22-yarder to Deondre Farrier and East Carolina was never threatened.

Moore threw for 187 yards and three touchdowns for Cincinnati (3-8, 1-6).