The 2024 women's college basketball tournament is set to tip off as Iowa's Caitlin Clark seeks to cap off her remarkable college career with a title, but standing in the Hawkeyes' way is a field of 68 teams featuring, among others, an undefeated South Carolina squad as well as defending champions LSU and perennial powerhouses UConn and Stanford as well as fellow No.1 seeds USC and Texas.
Keep reading to see the pregame lines, spreads and totals from each of the opening round matchups. Catch every game from the First Four to the Final Four and the championship on ABC, ESPN, ESPN2, ESPNU and ESPNEWS.
Odds by ESPN BET 
as of publication time.
(3) NC State Wolfpack -4.5
(6) Tennessee Lady Volunteers
Reynolds Coliseum, Raleigh, N.C., 4 p.m. ET
NC State: 27-6, 13-5 in ACC play
Tennessee: 19-12, 10-6 in SEC play
Money line: NC State (+160) Tennessee (-225) Total: 140.5
BPI Projection: NC State by 6.8 points, straight up 73.6% of the time
(6) Syracuse Orange
(3) UConn Huskies -20.5
Gampel Pavilion, Storrs, Conn., 6 p.m. ET
Syracuse: 23-7, 13-5 in ACC play
UConn: 29-5, 18-0 in Big East play
Money line: Syracuse (+1600) UConn (-20000) Total: 144.5
BPI Projection: UConn by 18.7 points, straight up 94.4% of the time
(5) Oklahoma Sooners
(4) Indiana Hoosiers -8.5
Simon Skjodt Assembly Hall, Bloomington, Ind., 6:30 p.m. ET
Oklahoma: 22-9, 15-3 in Big 12 play
Indiana: 24-5, 15-3 in Big Ten play
Money line: Oklahoma (+270) Indiana (-500) Total: 155.5
BPI Projection: Indiana by 9.3 points, straight up 80.3% of the time
(8) West Virginia Mountaineers
(1) Iowa Hawkeyes -14.5
Carver-Hawkeye Arena, Iowa City, Iowa, 8:00 p.m. ET
West Virginia: 24-7, 12-6 in Big 12 play
Iowa: 29-4, 15-3 in Big Ten play
Money line: West Virginia (+600) Iowa (-2000) Total: 163.5
BPI Projection: Iowa by 10.8 points, straight up 83.6% of the time
(7) Creighton Bluejays
(2) UCLA Bruins -8.5
Pauley Pavillion, Los Angeles, 8:30 p.m. ET
Creighton: 25-5, 15-3 in Big East play
UCLA: 25-6, 13-5 in Pac-12 play
Money line: Creighton (+320) UCLA (-600) Total: 139.5
BPI Projection: UCLA by 12.1 points, straight up 86.1% of the time
(8) Kansas Jayhawks
(1) USC Trojans -10.5
Galen Center, Los Angeles, 10 p.m. ET
Kansas: 19-12, 11-7 in Big 12 play
USC: 26-5, 13-5 in Pac-12 play
Money line: Kansas (+400) USC (-900) Total: 130.5
BPI Projection: USC by 9.4 points, straight up 80.6% of the time
(5) Utah Utes
(4) Gonzaga Bulldogs -1.5
McCarthey Athletic Center, Spokane, Wash., 10:30 p.m. ET
Utah: 22-10, 11-7 in Pac-12 play
Gonzaga: 30-3, 16-0 in WCC play
Money line: Utah (-105) Gonzaga (-130) Total: 144.5
BPI Projection: Gonzaga by 1.9 points, straight up 57% of the time