Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the Expected XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All Expected XIs and injury news powered by Rotowire, subject to updates.)
Brentford v Everton
Gtech Community Stadium
Wednesday, 7.30 p.m. GMT / 2.30 p.m. ET
Latest Brentford team news
Expected Lineup:
GK Mark Flekken
LB Keane Lewis-Potter | CB Nathan Collins | CB Ethan Pinnock | RB Kristoffer Ajer
DM Vitaly Janelt | DM Yehor Yarmolyuk
LW Kevin Schade | AM Mikkel Damsgaard | RW Bryan Mbeumo
ST Yoane Wissa
Player availability updates:
Josh Dasilva, M, knee, OUT, estimated return Apr. 5
Rico Henry, M/D, hamstring, OUT, estimated return Mar. 8
Aaron Hickey, M/D, hamstring, OUT, estimated return Mar. 15
Mathias Jensen, M, groin, OUT, estimated return Mar. 8
Igor Thiago, F, infection, OUT, estimated return Mar. 15
Christian Nørgaard, M, concussion, OUT, estimated return Mar. 8
Gustavo Nunes, F/M, back, OUT, estimated return Apr. 12
Sepp van den Berg, D, knee, OUT, estimated return Mar. 8
Latest Everton team news
Expected Lineup:
GK Jordan Pickford
LB Vitaliy Mykolenko | CB Jarrad Branthwaite | CB James Tarkowski | RB Jake O'Brien
DM James Garner | DM Idrissa Gueye
LW Jack Harrison | AM Abdoulaye Doucouré | RW Jesper Lindstrom
ST Beto
Player availability updates:
Armando Broja, F, ankle, OUT, estimated return Mar. 8
Dominic Calvert-Lewin, F, hamstring, OUT, estimated return Mar. 8
Seamus Coleman, D, calf, OUT, estimated return Mar. 15
Orel Mangala, M, knee, OUT, estimated return Sep. 10
Dwight McNeil, F/M, knee, OUT, estimated return Apr. 2
Iliman Ndiaye, F/M, knee, OUT, estimated return Mar. 8
Nathan Patterson, D, hamstring, OUT, estimated return Mar. 8
Youssef Chermiti, F, undisclosed, OUT, estimated return Mar. 8
Manchester United v Ipswich Town
Old Trafford
Wednesday, 7.30 p.m. GMT / 2.30 p.m. ET
Latest Manchester United team news
Expected Lineup:
GK André Onana
CB Matthijs de Ligt | CB Harry Maguire | CB Noussair Mazraoui
LM Patrick Dorgu | CM Bruno Fernandes | CM Manuel Ugarte | RM Diogo Dalot
AM Alejandro Garnacho | AM Joshua Zirkzee
ST Rasmus Højlund
Player availability updates:
Altay Bayindir, G, undisclosed, OUT, estimated return Mar. 2
Toby Collyer, M, undisclosed, OUT, estimated return Mar. 2
Amad Diallo, F/M, ankle, OUT, estimated return Jun. 30
Jonny Evans, D, undisclosed, OUT, estimated return Mar. 2
Kobbie Mainoo, M, undisclosed, OUT, estimated return Apr. 1
Lisandro Martínez, D, knee, OUT, estimated return Oct. 1
Mason Mount, F/M, strain, OUT, estimated return Mar. 9
Luke Shaw, D, calf, OUT, estimated return Mar. 1
Latest Ipswich Town team news
Expected Lineup:
GK Alex Palmer
LB Leif Davis | CB Jacob Greaves | CB Dara O'Shea | RB Axel Tuanzebe
DM Sam Morsy | DM Jack Taylor
LW Nathan Broadhead | AM Omari Hutchinson | RW Jaden Philogene
ST Liam Delap
Player availability updates:
Wes Burns, F/M, knee, OUT, estimated return Sep. 13
Jens Cajuste, M, ankle, DOUBT
Conor Chaplin, F/M, knee, DOUBT
Julio Enciso, F/M, knee, OUT, estimated return Mar. 15
Chiedozie Ogbene, F/M, achilles, OUT, estimated return May. 3
Kalvin Phillips, M, calf, DOUBT
Christian Walton, G, groin, OUT, estimated return Apr. 5
Nottingham Forest v Arsenal
The City Ground
Wednesday, 7.30 p.m. GMT / 2.30 p.m. ET
Latest Nottingham Forest team news
Expected Lineup:
GK Matz Sels
LB Neco Williams | CB Murillo | CB Nikola Milenkovic | RB Ola Aina
DM Elliot Anderson | DM Danilo Oliveira
LW Callum Hudson-Odoi | AM Morgan Gibbs-White | RW Anthony Elanga
ST Chris Wood
Player availability updates:
Carlos Miguel, G, hamstring, OUT, estimated return Mar. 15
Danilo Oliveira, M, undisclosed, DOUBT
Latest Arsenal team news
Expected Lineup:
GK David Raya
LB Riccardo Calafiori | CB Gabriel Magalhães | CB William Saliba | RB Jurriën Timber
CM Martin Ødegaard | CM Declan Rice | CM Thomas Partey
FWL Leandro Trossard | ST Mikel Merino | FWR Ethan Nwaneri
Player availability updates:
Kai Havertz, F/M, hamstring, OUT, estimated return Aug. 1
Gabriel Jesus, F, knee, OUT, estimated return Oct. 1
Myles Lewis-Skelly, M/D, suspension, due back Mar. 4
Gabriel Martinelli, F/M, hamstring, OUT, estimated return Mar. 11
Bukayo Saka, F/M, hamstring, OUT, estimated return Mar. 16
Takehiro Tomiyasu, D, knee, OUT, estimated return Dec. 1
Tottenham Hotspur v Manchester City
Tottenham Hotspur Stadium
Wednesday, 7.30 p.m. GMT / 2.30 p.m. ET
Latest Tottenham Hotspur team news
Expected Lineup:
GK Guglielmo Vicario
LB Djed Spence | CB Kevin Danso | CB Archie Gray | RB Pedro Porro
DM Rodrigo Bentancur | DM Lucas Bergvall
LW Son Heung-Min | AM James Maddison | RW Dejan Kulusevski
ST Mathys Tel
Player availability updates:
Ben Davies, D, undisclosed, OUT, estimated return Mar. 9
Richarlison, F, calf, OUT, estimated return Mar. 9
Radu Dragusin, D, knee, OUT, estimated return Oct. 1
Cristian Romero, D, quadriceps, OUT, estimated return Mar. 6
Dominic Solanke, F, knee, OUT, estimated return Mar. 8
Micky van de Ven, D, undisclosed, OUT, estimated return Mar. 6
Timo Werner, F/M, hamstring, DOUBT
Latest Manchester City team news
Expected Lineup:
GK Ederson
LB Josko Gvardiol | CB Rúben Dias | CB Abdukodir Khusanov | RB Rico Lewis
CM Bernardo Silva | CM Nicolas Gonzalez | CM Ilkay Gündogan
FWL Phil Foden | ST Omar Marmoush | FWR Savinho
Player availability updates:
Manuel Akanji, D, groin, OUT, estimated return Apr. 19
Oscar Bobb, F/M, leg, DOUBT
Erling Haaland, F, knee, DOUBT
Rodri, M, knee, OUT, estimated return Jul. 1
John Stones, D, thigh, OUT, estimated return Apr. 19
Liverpool v Newcastle United
Anfield
Wednesday, 8.15 p.m. GMT / 3.15 p.m. ET
Latest Liverpool team news
Expected Lineup:
GK Alisson Becker
LB Andrew Robertson | CB Ibrahima Konaté | CB Virgil van Dijk | RB Trent Alexander-Arnold
DM Ryan Gravenberch | DM Alexis Mac Allister
LW Luis Díaz | AM Dominik Szoboszlai | RW Mohamed Salah
ST Cody Gakpo
Player availability updates:
Conor Bradley, D, undisclosed, OUT, estimated return Mar. 11
Joe Gomez, D, hamstring, OUT, estimated return Apr. 26
Tyler Morton, M, shoulder, OUT, estimated return Mar. 8
Latest Newcastle United team news
Expected Lineup:
GK Nick Pope
LB Lewis Hall | CB Dan Burn | CB Fabian Schär | RB Valentino Livramento
CM Bruno Guimaraes | CM Lewis Miley | CM Joe Willock
FWL Anthony Gordon | ST Alexander Isak | FWR Jacob Murphy
Player availability updates:
Sven Botman, D, knee, DOUBT
Joelinton, F/M, knee, OUT, estimated return Mar. 2
Jamaal Lascelles, D, knee, OUT, estimated return May. 3
West Ham United v Leicester City
London Stadium
Thursday, 8 p.m. GMT / 3 p.m. ET
Latest West Ham United team news
Expected Lineup:
GK Alphonse Areola
LB Oliver Scarles | CB Aaron Cresswell | CB Max Kilman | CB Jean-Clair Todibo | RB Aaron Wan-Bissaka
CM Edson Álvarez | CM Tomás Soucek | CM James Ward-Prowse
ST Jarrod Bowen | ST Mohammed Kudus
Player availability updates:
Michail Antonio, F, leg, OUT, estimated return Dec. 1
Vladimír Coufal, D, hamstring, DOUBT
Niclas Füllkrug, F, hamstring, OUT, estimated return Mar. 15
Lucas Paquetá, F/M, ankle, OUT, estimated return Mar. 10
Crysencio Summerville, F/M, hamstring, OUT, estimated return Apr. 1
Latest Leicester City team news
Expected Lineup:
GK Mads Hermansen
LB Victor Kristiansen | CB Wout Faes | CB Jannik Vestergaard | RB Woyo Coulibaly
DM Wilfred Ndidi | DM Boubakary Soumaré
LW Stephy Mavididi | AM Bilal El Khannouss | RW Facundo Buonanotte
ST Jamie Vardy
Player availability updates:
Odsonne Édouard, F, undisclosed, OUT, estimated return Mar. 9
Fatawu Issahaku, F, knee, OUT, estimated return Aug. 25
James Justin, D, foot, OUT, estimated return Feb. 27
Caleb Okoli, D, undisclosed, DOUBT
Ricardo Pereira, D, hamstring, OUT, estimated return Mar. 9