Giant Killer upsets to watch in Midwest Region

Other regions: South | East | West

It's upset time, baby. We've gone deep once again in analyzing each of the six Giant vs. Killer matchups for each of the four regions. Remember, a Giant Killer is any team that beats an opponent seeded at least five spots higher. See our full methodology for more details.

We are utilizing our standard categories of Best Bets, Worth A Long Look, Not Completely Crazy and Stay Away. If you object to a game's placement, you're arguing with math. Our statistical model generates upset odds for each game. Those odds are based on three key factors: basic power ratings, teams' "Secret Sauce" (their statistical similarity to past Davids and Goliaths) and the matchup between Giants and Killers' playing styles. This year, we introduced a similar games component that is not yet a predictive part of the model, but it added interesting insights. Below each game's upset odds, you'll find data on how similar GK games dating back to 2007 turned out.