Alun Wyn Jones will return to captain Wales against France in Cardiff on Saturday, but there is no place for Steff Evans or Aaron Shingler.
Evans and Shingler have been among Wales' top performers during the championship but coach Warren Gatland has opted to pair Liam Williams and George North on the wings, while Justin Tipuric retains his place in the back row.
Rob Evans, Ken Owens and Josh Navidi all return to the pack alongside skipper Jones, meaning there is no place in the matchday squad for Ross Moriarty.
Leigh Halfpenny -- a second-half replacement against Italy last weekend -- returns at fullback, while Dan Biggar and Scott Williams are also picked to start.
Samson Lee has recovered from the illness that sidelined him against the Italians to take his place on the bench, where he is joined by Shingler, Evans and Gareth Anscombe.
"There have been some tough selection calls, but that is exactly what we want, we want to be in a position where there are selections and decisions to be made and we have had to make some tough ones this weekend," Wales coach Warren Gatland said.
"We have picked a team and a squad we believe can deliver this weekend against France."
Wales squad to face France:
Halfpenny, North, S. Williams, Parkes, L. Williams, Biggar, G. Davies; R. Evans, Owens, Francis, Hill, A.W. Jones, Tipuric, Navidi, Faletau.
Replacements: Dee, Smith, Lee, B. Davies, Shingler, A. Davies, Anscombe, S. Evans.