UConn and Alabama have already clinched their spots in the Final Four, and today we find out the other two teams. The top two seeds in the midwest, Purdue and Tennessee, will take the court in Detroit to punch their ticket to Arizona.
In the late game, the ACC is guaranteed to get a team in the Final Four, as tournament darlings NC State will look to reach the Final Four for the first time since winning it all in 1983. In their way, conference rivals Duke, who seek their second Final Four appearance in the past three seasons.
Keep reading to see the pregame lines, spreads and totals from each of the opening-round matchups.
Odds by ESPN BET 
as of publication time.
Sunday
(2) Tennessee Volunteers
(1) Purdue Boilermakers -3.5
Little Caesars Arena, Detroit, 2:20 p.m. ET
Money line: Tennessee (+140) Purdue (-165) Total: 147.5
Tennessee: 24-8, 14-4 in SEC play
Purdue: 29-4, 17-3 in Big Ten play
BPI Projection: Purdue by 3.2 points, straight up 62.1% of the time
(11) NC State Wolfpack
(4) Duke Blue Devils -6.5
American Airlines Center, Dallas, 5:05 p.m. ET
Money line: NC State (+250) Duke (-300) Total: 143.5
NC State: 22-14, 9-11 in ACC play
Duke: 24-8, 15-5 in ACC play
BPI Projection: Duke by 10.8 points, straight up 84.6% of the time