Who should you start? Who should you sit? To help you set your fantasy football lineups and to avoid starting a player who won't be in the lineup, we'll post fantasy-relevant updates and analysis here as NFL teams release their official inactives lists, typically about 90 minutes before kickoff. Any rankings cited in this column come from our ESPN Fantasy staff ranks.
Official Sunday inactives should begin coming in approximately 90 minutes prior to the scheduled kickoff time, including around 11:30 a.m. ET for the early games and 2:30 p.m. ET for the late games.
Refresh often for the latest information.
4 p.m. ET games
Offense
Chase Edmonds, RB, ARI: Shoulder -- Active
Impact: He will play, but remember that James Conner got more touches last week.
Zach Ertz, TE, ARI: Ineligible -- Inactive
Impact: Because he played for Philadelphia on Thursday, Ertz is not allowed to play for his new team this week.
Nick Chubb, RB, CLE: Calf -- OUT
Impact: His absence opens the door for Hunt to shine as an RB1.
Kareem Hunt, RB, CLE: Wrist -- Active
Impact: Demetric Felton and D'Ernest Johnson are all that's left if he can't play a full game.
Jarvis Landry, WR, CLE: Knee -- OUT
Impact: He has made enough progress, however, to likely play in Week 7.
Ezekiel Elliott, RB, DAL: Ribs -- Active
Impact: There was never a chance Elliott would sit this one out.
Melvin Gordon III, RB, DEN: Hip -- Active
Impact: Javonte Williams will get looks regardless. Also, Mike Boone is back from IR.
Damien Harris, RB, NE: Ribs -- Active
Impact: Rhamondre Stevenson seems to be Bill Belichick's RB flavor of the week at the moment.
J.J. Taylor, RB, NE: Groin -- Inactive
Impact: Brandon Bolden will also potentially be in the backfield mix.
Nick Folk, K, NE: Knee -- Active
Impact: Again, this status was just precautionary. Folk is playing.
Defense
Byron Murphy Jr., CB, ARI: Ribs -- Active
Chandler Jones, LB, ARI: COVID-19 -- OUT
Jadeveon Clowney, DE, CLE: Knee -- Active
Myles Garrett, DE, CLE: Knee -- Active
Malcolm Smith, LB, CLE: Abdomen -- OUT
Denzel Ward, CB, CLE: Neck -- Active
Greg Newsome II, CB, CLE: Calf -- Active
Dorance Armstrong, DE, DAL: Ankle -- OUT
Damontae Kazee, S, DAL: Hip -- Active
Donovan Wilson, S, DAL: Groin -- Active
Trevon Diggs, CB, DAL: Ankle -- Active
Kareem Jackson, S, DEN: Back -- Active
Johnathan Hankins, DT, LV: Hip -- Inactive
Quinton Jefferson, DT, LV: Back -- Active
Kyle Van Noy, LB, NE: Groin -- Active
Jalen Mills, CB, NE: Hamstring -- Active
Sunday night game
Russell Wilson, QB, SEA: Finger -- OUT/IR
Impact: Geno Smith will be under the microscope in this one.
Chris Carson, RB, SEA: Neck -- OUT/IR
Impact: Alex Collins to start, with DeeJay Dallas backing him up.
JuJu Smith-Schuster, WR, PIT: Shoulder -- OUT/IR
Impact: Chase Claypool and James Washington will have big shoes to fill.
9:30 a.m. ET London game
Jacoby Brissett, QB, MIA: Hamstring -- Active
Impact: Tua Tagovailoa is off the IR and will start in Week 6.
DeVante Parker, WR, MIA: Shoulder -- OUT
Impact: Isaiah Ford was promoted from the practice squad to supplement Miami's WR depth.
Preston Williams, WR, MIA: Groin -- Inactive
Impact: Mack Hollins and Albert Wilson should see extra looks.
Adam Shaheen, TE, MIA: Knee -- Inactive
Impact: Durham Smythe will be expected to step up, as the overseas travel certainly did Shaheen no favors.
Xavien Howard, CB, MIA: Shoulder -- OUT
Byron Jones, CB, MIA: Achilles -- Inactive
Roy Robertson-Harris, DT, JAX: Ankle -- Active
Myles Jack, LB, JAX: Back -- OUT
1 p.m. ET games
Offense
Sammy Watkins, WR, BAL: Thigh -- OUT
Impact: Rashod Bateman comes off IR and will make his debut.
Ty'Son Williams, RB, BAL: Team decision -- Inactive
Impact: The team obviously trusts its trio of veterans more in the backfield.
Christian McCaffrey, RB, CAR: Hamstring -- OUT/IR
Impact: Chuba Hubbard to continue to start until at least Week 9.
Damien Williams, RB, CHI: COVID-19 -- OUT
Impact: Khalil Herbert is pretty much all there is in Chicago's backfield.
Allen Robinson II, WR, CHI: Ankle -- Active
Impact: Breshad Perriman, however, is a surprise inactive for this one.
Joe Mixon, RB, CIN: Ankle -- Active
Impact: Expectations are for Mixon to handle a full workload.
Jamaal Williams, RB, DET: Hip -- Active
Impact: Jermar Jefferson might get a few touches if Williams can't go a full 60 minutes.
D'Andre Swift, RB, DET: Groin -- Active
Impact: Swift is expected to start and see his usual complement of touches.
T.J. Hockenson, TE, DET: Knee -- Active
Impact: Hockenson will play after being able to practice all week.
Danny Amendola, WR, HOU: Thigh -- Inactive
Impact: Another missed game for Amendola, who also sat out last week.
Rodrigo Blankenship, K, IND: Hip -- OUT/IR
Impact: Michael Badgley will kick in his stead.
Jordan Wilkins, RB, IND: Illness -- OUT
Impact: Marlon Mack could be showcased a bit amid trade rumors.
T.Y. Hilton, WR, IND: Neck -- Active
Impact: He has returned to practice and could see limited action Sunday.
Tyreek Hill, WR, KC: Quad -- Active
Impact: Byron Pringle and Josh Gordon might get some extra work if he stumbles.
Mike Williams, WR, LAC: Knee -- Active
Impact: This was a game-time call, so Jalen Guyton and Joshua Palmer could still see some increased action.
Saquon Barkley, RB, NYG: Ankle -- OUT
Impact: His injury looked quite serious, so it's not a surprise he's missing Week 6.
Kenny Golladay, WR, NYG: Knee -- OUT
Impact: While QB Daniel Jones will play, Golladay's knee will keep him sidelined.
Darius Slayton, WR, NYG: Hamstring -- Inactive
Impact: Sterling Shepard to see the majority of WR targets.
Kadarius Toney, WR, NYG: Ankle -- Active
Impact: He will also play and get a ton of work on this depleted WR squad.
Antonio Gibson, RB, WAS: Shin -- Active
Impact: J.D. McKissic is still the safer fantasy play.
Terry McLaurin, WR, WAS: Hamstring -- Active
Impact: He was reported to be feeling better on Saturday, so his active status today was expected.
Curtis Samuel, WR, WAS: Groin -- OUT
Impact: Adam Humphries should start alongside McLaurin.
Cam Sims, WR, WAS: Hamstring -- OUT
Impact: DeAndre Carter and Dax Milne will provide WR depth.
Dyami Brown, WR, WAS: Knee -- Active
Impact: Antonio Gandy-Golden was also promoted to the active roster, just in case.
Defense
DeShon Elliott, S, BAL: Quad -- Active
Shaq Thompson, LB, CAR: Foot -- OUT
Akiem Hicks, DE, CHI: Groin -- Active
Khalil Mack, LB, CHI: Foot -- Active
Eddie Jackson, S, CHI: Knee -- Active
Trey Flowers, DE, DET: Knee -- Active
Kevin King, CB, GB: Shoulder -- OUT
Desmond King II, CB, HOU: Hip -- Active
Xavier Rhodes, CB, IND: Concussion -- Active
Chris Jones, DT, KC: Wrist -- OUT
Anthony Hitchens, LB, KC: Knee -- Active
Charvarius Ward, CB, KC: Quad -- Inactive
Drue Tranquill, LB, LAC: Chest -- OUT
Nasir Adderley, S, LAC: Hip -- Inactive
Michael Pierce, DT, MIN: Elbow -- OUT