In their place, Xavi has called up eight academy players. Defenders Hector Fort and Pau Cubarsí have both been named in the squad along with midfielders Marc Casadó and Aleix Garrido and forwards Ángel Alarcón and Marc Guiu, who scored on his first-team debut in October.
The Spanish champions have yet to wrap up top spot, but it would take a defeat to Antwerp, a Shakhtar Donetsk win in Porto and a seven goal swing for them to not progress as group winners.
Domestically, Xavi's side fell seven points behind leaders Girona on Sunday as they lost for just the second time in LaLiga this season, but the Barça coach insisted the performance was not as bad as the result suggested.
"It is a disastrous result, but the performance was not disastrous," Xavi told in a news conference after the defeat.
"It's a big blow because we were hoping to get back within two points of the leaders.
"This is the reality. It's a Barça side in construction. These things happen when you are building, taking a step back to hopefully take two forward.
"Today, things didn't come off for us, but on another day they could have. We can't have any doubts. It was not a bad performance. Last year we also faced setbacks, but we went on to win two trophies."