After the game, manager Joe Maddon said that X-rays were negative, but Bryant isn't expected to play on Wednesday.
The 2016 National League MVP was hit in the wrist by a pitch from Chris Archer during the fourth inning on Tuesday night. Ian Happ replaced him at third base in the sixth after entering as a pinch hitter in the fifth.
The 26-year-old Bryant was on the disabled list from July 26 to Sept. 1 with left shoulder inflammation. He missed time earlier in the season with the same issue.