With under three months to go until the European Championship finals, the fear of missing out will be in the back of the minds of many a Premier League player.
Some have already been ruled out while others face an anxious wait. ESPN FC picks out six stars struck by injury.
Wayne Rooney (England)
The build-up for an England appearance at a major finals would not be complete without a Rooney injury riddle. Recent reports suggested the national captain will return in April following the knee injury that has kept him out since Manchester United's 2-1 defeat at Sunderland on Feb. 13.
England manager Roy Hodgson can try out other options in the incoming friendlies with Germany and Netherlands, but Rooney, who showed imperious goalscoring form in qualifying, scoring seven times, would be sorely missed.
England must hope that Rooney's return happens sooner rather than later, as his poor showings at the 2006 and 2010 World Cups and Euro 2012 all owed much to his lack of match sharpness after recovering from injury.
Prognosis: Expected to make it
Jack Wilshere (England)
Recent media briefings have suggested that Hodgson has a place set aside for Arsenal's midfielder, despite him not kicking a ball in anger all season. A broken leg suffered in training ahead of the Community Shield is set to keep him out until April, the latest in a worrying line of long-term injuries. The initial diagnosis of a hairline fracture suggested that he would only miss the opening weeks, but Arsenal fans are still waiting to see the former wonder boy in action.
Earlier this month, Arsenal manager Arsene Wenger revealed that Wilshere is back making training runs outdoors. "I believe he is out of the tunnel," said Arsenal's manager. That spells good news for Hodgson, who clearly thinks very high of the 24-year-old, who he likes to use as a deep-lying midfielder.
"I think he played four games on the trot [for England] and was man-of-the-match in all of them," Hodgson told TalkSport. "He is a very decisive player for us, even to such an extent that he has changed our style of play."
Prognosis: Doubtful to make it
Kurt Zouma (France)
Those at Stamford Bridge who saw Chelsea's central defender crash to the floor after an aerial challenge during last month's 1-1 draw with Manchester United will remember the crunch and the scream of pain as the 21-year-old hit the deck. It was swiftly apparent that his injury might be a season-ender, and the Euros were ruled out, too.
An anterior cruciate ligament injury was diagnosed and an operation was carried out in Barcelona. Zouma would have been back-up to Raphael Varane and Laurent Koscielny for Les Bleus, but his absence is a definite setback for coach Didier Deschamps.
Prognosis: Will not make it
Chris Brunt (Northern Ireland)
Brunt was just a year old when his country last played at a major tournament, the 1986 World Cup. The West Brom midfielder, who played out of position for his country in Euro qualifying, had given so much to help them to be in France this summer, only to see disaster strike when he sustained a cruciate knee ligament rupture in last month's 3-2 Baggies victory over Crystal Palace.
"To play as long as Chris has at international level and now to miss out on the finals is heart-breaking," said Northern Irish national manager Michael O'Neill. "I'm devastated for him and I'm devastated for the team as well."
It looks as if Brunt will be invited to be a part of the team's set-up in France, but his team will sorely miss his drive and expertise with corners and free kicks.
Prognosis: Will not make it
Marc Wilson (Republic of Ireland)
Across the border, Republic of Ireland coach Martin O'Neill is sweating on the fitness of Stoke City's central defender, who can also play at full-back or even in midfield, after he sustained a medial knee ligament injury during a 1-0 FA Cup defeat to Crystal Palace on Jan. 30.
"Marc is down at the moment, which you would expect," said Stoke manager Mark Hughes. "He is looking forward to the European Championship which is what he wants to be involved in at the end of the season."
Wilson's return, barring a setback, is expected at the beginning of May.
Prognosis: Expected to make it
Luke Shaw (England)
Sadly for Shaw, his Euro 2016 dream was ended as early as Sept. 25 when a heavy challenge from PSV Eindhoven's Hector Moreno broke his right leg in two places. Just 20 days earlier, when England confirmed their Euro qualification by winning 6-0 in San Marino, the Manchester United player had starred at left-back.
Van Gaal suggested in February that the 20-year-old could be fit by the middle of May and reports from the United training ground have hinted Shaw may play for United before the end of the season. Hodgson has also refused to rule the player out but Shaw's chances of being in France look slim.
Prognosis: Will not make it