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West Ham were eliminated from the Europa League on Thursday after losing 2-1 to FC Astra in Romania.
Slaven Bilic left a host of first-team players at home ahead of the second leg -- despite the fact it was hanging in the balance following a 2-2 draw at Upton Park a week ago -- and Astra advanced to the playoff round 4-3 on aggregate.
Things were looking up for the Premier League side when new signing Manuel Lanzini scored three minutes into his West Ham debut.
But the hosts responded after the half-hour mark when Constantin Budescu scored twice in a four-minute span to send his side through.
Southampton had a more comfortable trip to the Netherlands, defeating Vitesse Arnhem 2-0 to advance 5-0 on aggregate.
It only took four minutes for Southampton to open the scoring as Dusan Tadic's whipped cross found James Ward-Prowse, with Graziano Pelle taking the ball and turning before sending a low, left-footed strike past Eloy Room.
Sadio Mane completed the rout late on after robbing Chelsea loanee Danilo Pantic and running in on goal, with his low shot beating Room.
Henrik Mkhitaryan recorded a hat trick as Borrusia Dortmund routed Wolfsberger AC 5-0.
The Austrian side, trailing 1-0 after the first leg, kept it close in the first half and Dortmund could not break through until Marco Reus scored in the 48th minute.
Pierre-Emerick Aubameyang added a second before Mkhitaryan scored his first on a low 30-yard strike. The Armenian then added two more to send Dortmund through 6-0 on aggregate.
Aberdeen were eliminated after drawing 1-1 against Kairat Almaty, with the Kazakhstan club advancing 3-2 on aggregate.
The Dons looked capable of progressing right up until the moment Gerard Gohou opened the scoring after 59 minutes.
Kenny McLean levelled on the night, but Aberdeen could not muster the second goal that would have seen them take the tie into extra time.
St Etienne reached the playoff round despite a 2-1 defeat at home to Targu Mures, who could not overturn a first-leg deficit and lost by an aggregate score of 4-2.
Luis Pedro and Ivan Lopez kept the Romanian side in contention until a 72nd-minute own goal by Pedro made the lead comfortable for the Ligue 1 club.
Fellow French side Bordeaux advanced 4-2 after Isaac Kiese Thelin's goal secured a 1-0 victory away to AEK Larnaka.
Both sides finished with 10 men as Clement Chantome and Juanma Ortiz both saw red.
Jelle van Damme scored in the 68th minute to give Standard Liege a 1-0 win over Zeljeznicar in Sarajevo to complete a 3-1 victory over the two legs.
Markus Henriksen and Joris van Overeem scored to lift AZ Alkmaar to a 2-1 win away to Istanbul Basaksehir.
A Doka Madureira goal was not enough for the Turkish side, who lost 4-1 on aggregate.
Sampdoria won 2-0 away to Vojvodina, but it was far too little after the Serie A side's embarrassing 4-0 defeat at home in the first leg.
Eder and Luis Muriel provided the goals but it was the Serbian club who advanced 4-2 on aggregate.
Athletic Bilbao managed a 0-0 draw against Inter Baku and advanced thanks to their 2-0 advantage from the first leg.