Marquez left his start Wednesday against Cleveland after feeling a sharp pain in his elbow in the bottom of the fourth inning on his 58th pitch of the game. He was making his first start since April 10, when he left his start against St. Louis with right forearm tightness.
He was placed on the 15-day IL the next day.
Marquez is 2-2 with a 4.95 ERA in four starts this season. He is two strikeouts shy of tying Jorge De La Rosa for Colorado's franchise record of 985.
Right-hander Connor Seabold was recalled from Triple-A Albuquerque to fill Marquez's roster spot.