Pirates designated hitter Andrew McCutchen and shortstop Oneil Cruz were both injured running the bases and removed in the seventh inning Friday night during a 5-3 win over the Seattle Mariners.
McCutchen singled to left field with one out and began limping just as he reached first base. Ji Hwan Bae ran for McCutchen, who extended his hitting streak to a season-high 11 games.
Two batters later, Cruz hit a two-run double to right field and stumbled as he rounded second base. Jared Triolo replaced him as a pinch runner.
McCutchen was diagnosed with left knee discomfort and Cruz with left ankle discomfort.
The Pirates snapped a 10-game skid Friday.
The Associated Press contributed to this report.