Gold Coast captain Tino Fa'asuamaleaui will miss the rest of the season after scans confirmed he tore his anterior cruciate ligament against Canterbury on Saturday.
The Titans confirmed the 24-year-old representative prop had scans in Sydney on Saturday night after the side's 32-0 loss and a further analysis by a club doctor on Sunday morning reinforced the worst possible news.
Fa'asuamaleaui, the team's best player, was assisted from the field in the 66th minute at Belmore after his right knee twisted when he was carrying the football.
The injury has left the Titans in a dire situation after their winless start to the season, which includes a 28-4 loss to St George Illawarra where Fa'asuamaleaui ran for 182 metres and made 28 tackles in a standout display in a badly beaten team.
The Titans have already had an injury-ravaged start to the season with fullback Jayden Campbell (patella) and second-rower David Fifita (torn pectoral) yet to play in the NRL.
Campbell returned to action on Saturday in the Queensland Cup with Tweed Heads and could be available for the round four NRL clash with the Dolphins on Saturday at Robina.
In a positive development, Queensland powerhouse Fifita trained the past fortnight without a pink no-contact bib after he tore a pec at training in December.
Campbell and Fifita will add strike to the Titans but Fa'asuamaleaui is the side's spiritual leader and for far too long has carried the team on his back.
His loss is a devastating blow to the Titans' finals hopes and leaves coach Des Hasler with a massive void in what has already been a most underwhelming start to the season.
The injury is also a dagger in the heart of the Maroons ahead of this year's State of Origin series - the Titans skipper has played 12 consecutive Origin matches in which the Maroons have won three series.
His setback comes on the back of Queensland also losing Dolphins forward Tom Gilbert to a season-ending ACL injury.