The Wallabies will be forced into at least one positional shuffle after their thrilling victory over England, while coach Joe Schmidt attempts to keep his team's feet on the ground by playing down hopes of a grand slam.
Schmidt will be without skipper Harry Wilson, who scored a try in the 42-37 win at Twickenham and was one of Australia's best alongside back-row teammates Rob Valetini and Fraser McReight, prop Angus Bell and centre Len Ikitau, after the No. 8 left the field midway through the second half following a head knock.
Return-to-play protocols mean Wilson will miss Sunday's game [Monday morning AEDT] against Wales in Cardiff despite the Reds back-rower reporting no symptoms the day after Australia's victory in London.
Wilson was one of many Wallabies players who posted pictures of the team's celebrations to social media, while Ikitau went a step further and called out former England No. 9 Ben Youngs for his pre-match criticism of Australia, comments the scrum-half later acknowledged in a light-hearted post himself.
While it was hard to find an Australian player without a beaming smile from ear to ear, Schmidt was instead trying to keep a lid on celebrations and played down hopes that the Wallabies could go on to sweep their November tour, with Tests against Scotland and Ireland to follow the clash with Wales.
"The grand slam may still be alive. But we won't look too far ahead," the Wallabies coach said.
The win was Australia's fifth under the Kiwi to date, but first since they edged Argentina in similarly dramatic fashion to the weekend, back in August.
And the coach is unsure whether it will be the springboard his team needs to really kick on, admitting that he fully expected further dips would come in his measured rebuild.
"I'm not sure we've turned it around. I think we're turning," Schmidt added.
"Inevitably, progress is never linear, so there'll be a few peaks and troughs on the way further forward, but I've found a really good bunch of people, both in the staff and in the playing group.
"The players can grow confidence in themselves. And I thought some of the skill exhibited, some of the things we've been working really hard on, were certainly visible, which gives us a bit of confidence, certainly gives the players a bit of confidence.
"I think there's green shoots."
Wilson's head knock could meanwhile open up the opportunity for Schmidt to get a look at Will Skelton, after the towering second-rower was omitted from the matchday 23 to face England alongside Samu Kerevi, despite the Test being one of only three the duo is eligible for on tour.
While Schmidt was not asked about whether he would consider changes for Wales after the win at Twickenham - Wilson's prognosis was also unknown immediately after the match - the No. 8's absence would seemingly create the opportunity for Skelton to start in Cardiff.
That would however likely push Jeremy Williams to No. 6, a position the rising forward has played for the Western Force, while teammate Lukhan Salakaia-Loto was previously used on the side of the scrum by former Wallabies coach Michael Cheika and could loom as another option.
But with now just two Tests to get a look at Skelton and Kerevi, Schmidt is likely not to want to waste the opportunity to see whether both players can add something to what is an improving Wallabies cohort.
The Kiwi has previously stated his preference was to pick from home soil, which has meant that only Skelton, Kerevi and, earlier in the year, Marika Koroibete, have been involved with the Wallabies from outside Australia.
Wilson's omission will also mean a chance of captain for the first time in six Tests.
Just where Kerevi lands, meanwhile, also holds intrigue after Joseph-Aukuso Suaalii made a superb professional rugby debut in partnership with Ikitau in the Wallabies' midfield.
The NRL convert showed he had lost few of the rugby instincts from his childhood, and while there were a couple of minor defensive errors, Australia were able to play to his offload and aerial strengths.
Given Suaalii's performance and the fact that he will be plying his trade in Australia with the Waratahs next season - not in Japan like Kerevi - Schmidt may be keen to persist with the same centre combination that dominated their opposites in London.
Winger Dylan Pietsch is another injury concern, but try-scoring hero Max Jorgensen looms as a like-for-like replacement on the left wing if the youngster is ruled out of the Cardiff clash.