Michigan State's basketball game at No. 5 Iowa on Thursday night has been postponed because of COVID-19 issues with the Spartans.
Center Mady Sissoko and guard Steven Izzo, who is coach Tom Izzo's son, have tested positive, and the school said there was an additional positive test Wednesday afternoon.
The school said Thursday that it will not host Indiana on Sunday as scheduled either.
Michigan State and the Big Ten are working on options to reschedule the games against the Hawkeyes and Hoosiers.
Tom Izzo, who tested positive for the coronavirus in November, said his son and Sissoko are roommates. Both are currently isolated and will be held out of competition for 17 days, following Big Ten protocols.
"I'm really disappointed, but it just goes to prove that this can affect anyone,'' Tom Izzo said. "I feel so comfortable that me, my son and my players did everything possible and followed every protocol as best we could. I'm really, really impressed with the way they have conducted themselves. This virus does not discriminate and I can't emphasize enough how important it is to wear a mask, wash your hands and follow protocols."
The Associated Press contributed to this report.