The 33-year-old Cishek was sidelined by left hip inflammation. The right-hander is 3-5 with seven saves and a 3.58 ERA in 54 games this season.
The Cubs' bullpen is getting healthy again after dealing with a string of injuries. Pedro Strop, Brandon Kintzler and closer Craig Kimbrel also have been activated from the IL in the past couple weeks.
Infielder David Bote was optioned to Triple-A Iowa on Monday to make room for Cishek.
The Cubs also announced Tuesday that infielder Ben Zobrist will play for Double-A Tennessee on Thursday and Triple-A Iowa on Friday and Saturday.
Zobrist has been on the restricted list since May 8. He has been dealing with a divorce.