First baseman Gio Urshela, who was out of the starting lineup the past four games because of back soreness, sustained an injury trying to beat out a double play in the first inning.
He was tended to by a trainer for several minutes after he stumbled and fell while trying to beat out the inning-ending play. He played the bottom half of the first in the field before being replaced by Jared Walsh.
The Orange County Register reported that Urshela was on crutches with a hip issue and would be evaluated in Kansas City, where the Angels travel next.
Third baseman Anthony Rendon also drew injury concerns in the first inning after being hit by a pitch on the wrist.
Rendon played the full game, although he did not take a full swing his final two at-bats. He tried to bunt both times.
The Register reported that he was undergoing X-rays after the game.
Earlier in the day, the Angels placed shortstop Zach Neto on the 10-day injured list with a left oblique strain. He left Wednesday night's game after only one inning because of discomfort and had an MRI on Thursday. Andrew Velazquez was called up from Triple-A Salt Lake and started at shortstop.
--The Associated Press and Reuters contributed to this report.