"I don't anticipate him not being able to go," coach Sean McVay said when asked before Friday's practice about Henderson's game status. "He's going to play."
He was a limited participant in practices Wednesday and Thursday, according to the Rams' injury report, before being upgraded to full Friday. He's officially listed as questionable.
The Rams are 3-0 as they prepare for a division opener at SoFi Stadium.
In two games, Henderson has rushed for 123 yards and two touchdowns on 29 carries, while providing a consistent checkdown option out of the backfield for quarterback Matthew Stafford. Henderson has caught four passes for 46 yards.
In Henderson's absence against the Bucs, running back Sony Michel started and rushed for 67 yards on 20 carries. In three games, Michel, who was acquired during a late-summer trade with the New England Patriots, has rushed for 115 yards on 31 carries and has caught three passes for 12 yards.