Fudd went down in the first half, appearing to reinjure her right knee. She was playing in just her second game back after missing the previous eight after hurting the same knee in December, and she was a topic of conversation in the postgame media availability.
"She just tweaked something and they got some ice on it," UConn coach Geno Auriemma told SNY after the game. "It didn't sound serious at all."
Still, the injury leaves UConn with just seven healthy players, the minimum needed to put a team on the court.
"If Azzi's out any period of time, like if she doesn't play Tuesday, then we're right back to square one, right?" Auriemma said.
Aaliyah Edwards scored 17 points and grabbed 11 rebounds as the short-handed Huskies opened up a close game in the second half against the Hoyas.
The Huskies, who led by one point at the half, opened the third quarter on a 20-3 run to take control of the game. They led 44-31 after three quarters and used a 12-0 fourth-quarter run to go up 65-41 and put the game away.
Muhl said the team responded the same way it has all season -- with prayers for their teammate and renewed focus on the court.
"I feel like, I always say, we're kind of used to (injuries)," she said. "I don't know if that is a good thing to say or a bad thing to say, but we are kind of used to it and we're always hopeful still and hopefully she's going to be OK."
Brianna Scott led Georgetown (8-9, 1-7) with 11 points. Georgetown was up 13-11 after a quarter, forcing seven turnovers and keeping UConn without a basket for over six minutes.
Fudd broke another UConn scoring drought with a 3-pointer from the right baseline that put the Huskies back in front 14-13.
But she left the court with about three minutes left in the half after colliding with Georgetown's Ariel Jenkins. She came back after halftime with a bag of ice on her right knee and did not play.
The Huskies have now won 18 straight Big East games, and this one was Auriemma's second game back after missing several games with flu-like symptoms.
The Associated Press contributed to this report.