The 2025 men's NCAA tournament began with 68 teams looking to raise a banner and write their name into college basketball history. The Auburn Tigers, the overall No. 1 seed in the South, are looking to avenge their SEC tournament loss and claim the title as the best team in the country, but they'll face stiff competition from tournament favorites Duke and Florida as well as from fellow No. 1 seed Houston
The SEC made a big statement in sending 14 teams to the Big Dance with half of those making it through the first two rounds of the tournament, including Arkansas, vying for a Cinderella run as the only double-digit seed left standing.
Here are the lines, spreads and totals for the Sweet 16 round of play which will take place on Thursday and Friday.
Odds are accurate as of publication time. All times Eastern. For the latest odds, go to ESPN BET.
Thursday
(6) BYU Cougars
(2) Alabama Crimson Tide -5.5
East Region, 7:09 p.m., Prudential Center, Newark, NJ
BYU: 24-9, 14-6 in Big 12 play
Alabama: 25-8, 13-5 in SEC play
Odds by ESPN BET
Moneyline: Alabama (-215), BYU (+180) Total: 175.5
BPI Projection: Alabama by 3.8, straight up: 64.8%
(4) Maryland Terrapins
(1) Florida Gators -6.5
West Region, 7:39 p.m., Chase Center, San Francisco
Maryland: 25-8, 14-6 in Big Ten play
Florida: 29-4, 14-4 in SEC play
Odds by ESPN BET
Moneyline: Florida (-290), Maryland (+240) Total: 156.5
BPI Projection: Florida by 2.9, straight up: 61.6%
(4) Arizona Wildcats
(1) Duke Blue Devils -9.5
East Region, 9:39 p.m., Prudential Center, Newark, NJ
Arizona: 22-12, 14-6 in Big 12 play
Duke: 31-3, 19-1 in ACC play
Odds by ESPN BET
Moneyline: Duke (-550), Arizona (+380) Total: 153.5
BPI Projection: Duke by 7.2, straight up: 76%
(10) Arkansas Razorbacks
(3) Texas Tech Red Raiders -5.5
West Region, 10:09 p.m., Chase Center, San Francisco
Arkansas: 20-13, 8-10 in SEC play
Texas Tech: 25-8, 15-5 in Big 12 play
Odds by ESPN BET
Moneyline: Texas Tech (-240), Arkansas (+200) Total: 147.5
BPI Projection: Texas Tech by 6.1, straight up: 72.5%
Friday
(6) Ole Miss Rebels
(2) Michigan State Spartans -3.5
South Region, 7:09 p.m., State Farm Arena, Atlanta
Ole Miss: 22-11, 10-8 in SEC play
Michigan State: 27-6, 17-3 in Big Ten play
Odds by ESPN BET
Moneyline: Michigan State (-175), Ole Miss (+150) Total: 143.5
BPI Projection: Michigan State by 3.7, straight up: 64.5%
(3) Kentucky Wildcats
(2) Tennessee Volunteers -4.5
Midwest Region, 7:39 p.m., Lucas Oil Stadium, Indianapolis
Kentucky: 22-11, 10-8 in SEC play
Tennessee: 27-6, 12-6 in SEC play
Odds by ESPN BET
Moneyline: Tennessee (-190), Kentucky (+160) Total: 144.5
BPI Projection: Tennessee by 3.3, straight up: 63.1%
(5) Michigan Wolverines
(1) Auburn Tigers -8.5
South Region, 9:39 p.m., State Farm Arena, Atlanta
Michigan: 24-9, 14-6 in Big Ten play
Auburn: 28-5, 15-3 in SEC play
Odds by ESPN BET
Moneyline: Auburn (-425), Michigan (+320) Total: 153.5
BPI Projection: Auburn by 8.5, straight up: 79.5%
(4) Purdue Boilermakers
(1) Houston Cougars -7.5
Midwest Region, 10:09 p.m., Lucas Oil Stadium, Indianapolis
Purdue: 22-11, 13-7 in Big Ten play
Houston: 30-4, 19-1 in Big 12 play
Odds by ESPN BET
Moneyline: Houston (-380), Purdue (+290) Total: 132.5
BPI Projection: Houston by 8.4, straight up: 79.4%