West Ham striker Diafra Sakho has been ruled out for three months with a thigh injury.
Sakho, 25, who has scored five goals for the Hammers this season, will undergo surgery on Saturday.
The Senegal international suffered the injury as he attempted to shoot during the second half of West Ham's 1-1 draw with West Bromwich Albion last Sunday.
Andy Carroll, who recently recovered from an ankle operation, is likely to start in Sakho's absence when West Ham travel to Manchester United on Saturday.
Sakho joins Dimitri Payet and Enner Valencia on the sidelines with injuries beginning to take their toll at Upton Park.
NEWS: The Club have provided an update on @iamdiafrasakho after he consulted a specialist. https://t.co/QjhT0CQygO pic.twitter.com/ZGlGqwhNXW
- West Ham United FC (@whufc_official) December 4, 2015
"It's a big blow," West Ham manager Slaven Bilic said. "Those three injuries happened to three key players, especially in the offensive part of our game.
"Of course Carroll is important. It's him and [Nikica] Jelavic and [Michail] Antonio [that are available].
"With the three of them it's a massive blow, but it's a good chance for some of the other guys to step in and show their class."
Bilic is hopeful that Valencia will be available in a couple of weeks after an ankle injury, but Payet is set to be sidelined until February.