Kelly Stafford underwent a 12-hour surgery to remove a brain tumor. On Sunday, she posted on Instagram that she had left the hospital.
The Lions had told Matthew Stafford to take as much time off as needed this offseason, but he was at the training facility first thing Monday.
Lions general manager Bob Quinn said Stafford has asked for privacy for his family at this time. Kelly Stafford has posted multiple times on social media saying she has been overwhelmed by the support since she made her acoustic neuroma diagnosis public.
On Wednesday, Kelly Stafford posted to Instagram that she went back to the hospital due to complications tapering off steroids. She wrote that she will spend the night in the hospital.
There was no immediate indication how this development will affect Matthew Stafford's plan to work at the team facility.
ESPN's Adam Schefter contributed to this report.