In the past 10 seasons, teams that are 0-2 against the spread are 46-28 ATS in Week 3 (62.1%). In the past five seasons, they are 25-12 ATS (67.5%). Overs are 20-12 this season. That is the third-highest over rate in the first two weeks since 1986 when we have data (highest since 2011).
Last week, favorites went 14-2 outright (entering Monday), with seven favorites winning but not covering. The seven favorites winning but not covering ties the most in a single week in the Super Bowl era (since 1966).
Here are more notable odds and ends for Week 3 NFL betting.
Odds listed are from Caesars Sportsbook by William Hill and are subject to change.
Las Vegas Raiders at New England Patriots (-6 47.5), Sunday, 1 p.m. ET
New England is 51-26 ATS after a loss in the Bill Belichick era, including 40-15 ATS since 2003.
Since 2007, New England is 30-11 ATS at home when favored by less than seven points.
Each of the past eight times the Raiders played a prime-time game, their following game went under the total. The Raiders are 2-8 ATS after a prime-time game since 2017.
The Raiders are 3-7 ATS in 1 p.m. ET games in the current Jon Gruden era.
Los Angeles Rams at Buffalo Bills (-3, 47.5), Sunday, 1 p.m. ET
Los Angeles is 8-3 ATS in its past 11 games when the line is between +3 and -3.
Los Angeles is 13-5 ATS since the start of last season (2-0 this season).
Both Buffalo games have gone over the total this season. Prior to this season, the under was 31-18-1 in Buffalo games under Sean McDermott (since 2017), including the playoffs.
Houston Texans at Pittsburgh Steelers (-4, 45), Sunday, 1 p.m. ET
Pittsburgh has gone under the total in 14 of its past 18 regular-season games since the start of last season.
Pittsburgh is 7-13-2 ATS as a favorite since 2018 and 6-8-1 outright in that span as a favorite of less than 5 points (5-8-1 ATS).
Deshaun Watson is 13-6 ATS in the regular season as an underdog, including 9-3 ATS as an underdog of fewer than five points (8-4 outright).
San Francisco 49ers (-3.5, 41.5) at New York Giants, Sunday, 1 p.m. ET
Since 2017, New York is 6-18-1 ATS at home, including 2-14 ATS as a home underdog of less than seven points.
The over is 8-3-1 in San Francisco's past 12 regular-season games.
Tennessee Titans (-2.5, 48.5) at Minnesota Vikings, Sunday, 1 p.m. ET
Minnesota is 13-4 ATS since 2012 as a home underdog. Minnesota is 7-3 ATS as a home underdog under Mike Zimmer, including the playoffs.
Kirk Cousins is 2-9 ATS as an underdog since joining the Vikings in 2018.
Ryan Tannehill is 3-1 ATS as a road favorite since joining the Titans last season.
Washington Football Team at Cleveland Browns (-6.5, 45), Sunday, 1 p.m. ET
Cleveland has failed to cover in each of its past five games (1-4 SU) and is 3-10-1 ATS over its past 14 games dating to last season.
Washington is 1-4 ATS and SU over its past five games dating to last season. The total has gone over in four of the five games as well. Washington was the underdog in all five.
The under is 26-12 over Washington's last 38 games.
Washington has been an underdog 16 times since the start of last season. That's the second most in the NFL, behind only Miami (17 games as an underdog).
Cincinnati Bengals at Philadelphia Eagles (-6.5, 46), Sunday, 1 p.m. ET
Cincinnati is 13-0 ATS against Philadelphia in franchise history, the best mark by one team over another team in NFL history (9-3-1 outright).
Philadelphia has lost three straight games outright, all as a favorite, dating to last year's postseason. Since the start of last season, Philadelphia is 4-8 ATS as a favorite and 6-6 SU.
Teams that are 0-2 are 23-12 ATS when favored by at least six points in their third game since 1990.
Cincinnati has lost 14 straight road games outright, but is 9-5 ATS in those games (since Week 7 of 2018).
Chicago Bears at Atlanta Falcons (-3.5, 47.5), Sunday, 1 p.m. ET
Teams that are 0-2, like Atlanta, are 5-9 ATS when favored over 2-0 teams in the Super Bowl era. This is the first time a 2-0 team is at least a 3-point underdog to an 0-2 team since 2008 (0-2 Minnesota won and covered a 3-point spread over 2-0 Carolina).
Chicago has covered three straight meetings. Nine of the past 10 meetings went under the total.
Chicago is 1-6 ATS in its past seven road games.
Atlanta is 4-8 ATS as a home favorite since 2018.
New York Jets at Indianapolis Colts (-10, 44.5), Sunday, 1 p.m. ET
The only time Indianapolis has been a double-digit favorite in the past six seasons, it lost outright to Miami last year as an 11-point favorite.
New York is 11-21-1 ATS on the road in the past five seasons.
New York is 4-1 ATS and SU in the past five meetings dating back to the 2010 AFC wild-card game.
This is the first double-digit point spread this season.
Carolina Panthers at Los Angeles Chargers (-7, 43.5), Sunday, 4:05 p.m. ET
The over is 11-4 in Carolina's past 15 games.
The Chargers are 2-5-1 ATS since the start of last season when favored by seven or more points.
Teddy Bridgewater is 4-1 ATS since the start of last season when an underdog of seven or more points.
The Chargers are 4-9-1 ATS under head coach Anthony Lynn when favored by seven or more since the start of the 2018 season.
Detroit Lions at Arizona Cardinals (-6, 55.5), Sunday, 4:25 p.m. ET
Kliff Kingsbury is 11-6-1 ATS since becoming the Cardinals' head coach last season. This is just the third time he has been favored (1-1 SU and ATS).
Matt Patricia is 6-12 ATS over the past two seasons as Lions head coach.
Detroit has failed to cover in each of its past six road game and 11 of its past 13 games overall.
The over is 11-5 over Detroit's past 16 games.
Tampa Bay Buccaneers (-6, 43) at Denver Broncos, Sunday, 4:25 p.m. ET
Denver is 5-2 ATS in games in which Drew Lock starts and 6-5 ATS in games with any other starter since the beginning of last season.
Denver will be starting backup Jeff Driskel, who was 0-3 ATS as a starting quarterback for the Lions last season (4-4 career ATS).
Tom Brady is 2-4 ATS over the past three seasons when favored by six or more on the road.
Bruce Arians is 11-5 ATS as a road favorite of six or more points since becoming a full-time head coach in 2013. That includes a perfect 2-0 ATS record last season in that situation.
The over is 14-2 over Tampa Bay's last 16 games.
Dallas Cowboys at Seattle Seahawks (-4.5, 55.5), Sunday, 4:25 p.m. ET
Dallas is 8-2 ATS in its past 10 games as an underdog. Dallas is also 3-0 ATS against Seattle since the start of the 2017 season.
Russell Wilson is 7-11-1 ATS as a home favorite since the start of the 2017 season.
Dak Prescott is 8-5 ATS as a road underdog since entering the league in 2016.
Mike McCarthy is 5-10-1 ATS as an underdog since the start of the 2017 season (coaching Green Bay and Dallas).
Green Bay Packers at New Orleans Saints (-3.5, 52), Sunday, 8:20 p.m. ET
Drew Brees is 30-19-2 ATS in prime-time games in his career, including the playoffs (20-8-1 ATS at home).
All four previous meetings between Brees and Aaron Rodgers went over the total by an average of 17.4 PPG.
Green Bay is 4-1 outright as an underdog in the regular season under Matt LaFleur (4-1 ATS).
New Orleans is playing its second straight prime-time game. Teams playing their second straight prime-time game are 16-26-1 ATS in the past three seasons (106-126-3 ATS in last 20 seasons).
Kansas City Chiefs at Baltimore Ravens (-3.5, 54.5), Monday, 8:15 p.m. ET
Kansas City is 5-0-1 ATS as an underdog with Patrick Mahomes starting (4-2 SU). Kansas City is 10-2-1 ATS in its past 13 games as an underdog regardless of quarterback.
Baltimore has won 14 straight regular-season games outright, going 11-2-1 ATS during that span. Baltimore is 11-1 ATS in its last 12 regular-season games with six straight covers.
Mahomes is 10-2 ATS in September games with 28 passing TDs and zero interceptions.
In the past 20 seasons, reigning Super Bowl champions are 11-1 ATS as underdogs within the first three weeks of the season.
The over is 14-8-1 in Mahomes starts when the total is in the 50s (Kansas City is 14-8-1 ATS).
Entering this week, the highest total in Baltimore history is 52. As of Monday, this total is 52.