Mississippi has indefinitely suspended guard Marshall Henderson for a violation of team rules, the school announced Wednesday.
The suspension is a result of multiple failed drug tests, sources told ESPN's Jeff Goodman.
CBS earlier reported the suspension was connected to a drug test.
Henderson's suspension has been "brewing for a few weeks," said a source with direct knowledge of the situation. The source also said Henderson can come back to the team "if" he meets certain conditions.
"Since the season ended, we have talked a lot about Marshall taking a greater leadership role with our team. With that comes greater responsibility, and he must do a better job of living up to the high standard we expect from him and he desires from himself," Ole Miss coach Andy Kennedy said in a statement.
Henderson, a 6-foot-2 guard who started his career at Utah and then played at a junior college in Texas before transferring to Ole Miss, helped turn the Rebels into one of the most offensive-minded teams in the country. He led the SEC in scoring and helped Ole Miss win the SEC tournament and earn an NCAA tournament berth for the first time since 2002.
But the flamboyant guard also was known for his abrasive personality and he quickly became the player opposing teams loved to hate.
Most of Henderson's transgressions were fairly harmless -- such as popping his jersey at the Auburn crowd after hitting a game-clinching shot -- but he rarely missed an opportunity to needle opposing fans.
It's been an eventful offseason for Henderson, but for all the wrong reasons.
He wrote a message in April for the university's website, thanking Ole Miss fans for their support and vaguely apologizing to "anyone I offended." He said he would try to become a better leader in the future.
He was also reprimanded by the NCAA in June for making an "inappropriate gesture" after the Rebels' loss to LaSalle in the third round of the NCAA tournament.
Henderson came to Ole Miss with a history of discipline problems. He was arrested in both 2009 and 2011 and served time in jail after the second arrest because he violated his probation. Ole Miss has said the coaches were aware of Henderson's past when he signed with the program.
Information from ESPN college basketball reporter Jeff Goodman, ESPN.com senior college basketball writer Andy Katz and The Associated Press was used in this report.