The AFL fixture could be thrown into chaos unless Western Australian premier Mark McGowan backs down on his strict border stance.
The league has committed to an unchanged opening round starting March 18, but beyond that could prove difficult given West Coast and Fremantle will both play early games in Victoria.
The Dockers will tackle Melbourne at the MCG in round one, while the Eagles are due to play the Western Bulldogs at Marvel Stadium the following weekend.
Victoria, which on Friday recorded two new COVID-19 cases, is the only state still subject to any WA border restrictions.
AFL fixture boss Travis Auld concedes there may need to be alterations to the draw to fall in line with WA health advice.
"The challenge will be Fremantle coming to Victoria to play Melbourne," Auld told reporters on Friday.
"It presents an issue as it stands for Fremantle going back to WA, they would have to quarantine (for 14 days).
"Clearly we have to work with those clubs and the WA government to see if there is a better solution without compromising the health of the community."
McGowan is due to front the media about upcoming state election later on Friday and could be asked about the AFL's predicament.