After a thrilling Week 4 that saw the Ohio State Buckeyes defeat the Notre Dame Fighting Irish in a 17-14 nailbiter, Sam Hartman and company will head to Durham to face Riley Leonard and the No. 17 Duke Blue Devils. The Fighting Irish opened as 5.5-point favorites over the Blue Devils ahead of the prime-time matchup. Elsewhere in Week 1, another Top 25 showdown will be featured in the afternoon slot, when Quinn Ewers and the No. 3 Texas Longhorns face Jaylon Daniels and the No. 24 Kansas Jayhawks. With both teams undefeated, Kansas could look to make a statement against a Longhorns team that opened as a 17-point favorite.
Here are the betting lines, money lines and totals for Week 5 of the college football season.
All odds are courtesy of Caesars Sportsbook.
No. 10 Utah at No. 19 Oregon State (-3)
Friday, 9 p.m. ET, Reser Stadium, Corvallis, Oregon
Money Line: Utah (+115); Oregon State (-135)
Game Total: 45.5 points
FPI Favorite: Oregon State by 3.1 (58.3% chance to win outright)
Betting nuggets
Oregon State is 10-3 ATS as a favorite since the start of last season.
Utah has gone under the total in four consecutive games, tied for the longest active under streak in the FBS.
Utah is 13-3 ATS as a road underdog since the start of the 2014 season.
No. 6 Penn State (-26) at Northwestern
Saturday, noon ET, Ryan Field, Evanston, Illinois
Money Line: Penn State (-4500); Northwestern (+1550)
Game Total: 46 points
FPI Favorite: Penn State by 23.9 (93.4% chance to win outright)
Penn State has covered five consecutive games since the start of last season, tied with Liberty and Oklahoma for the longest active cover streak in FBS.
Penn State is 5-0 ATS as a road favorite since the start of last season.
Penn State is 8-2-1 ATS in Big Ten games since the start of last season.
Northwestern has an over percentage of .750 this season, highest in the Big Ten.
No. 8 USC (-23) at Colorado
Saturday, noon ET, Folsom Field, Boulder, Colorado
Money Line: USC (-14500); Colorado (+800)
Game Total: 73.5 points
FPI Favorite: USC by 19.8 (89.7% chance to win outright).
Colorado is 2-8 ATS following a straight-up loss since the start of last season.
Five of USC's six road games have gone over the total since the start of last season.
No. 22 Florida at Kentucky (-3)
Saturday, noon ET, Kroger Field, Lexington, Kentucky
Money Line: Florida (+135); Kentucky (-160)
Game Total: 46 points
FPI Favorite: Kentucky by 0.7 (52% chance to win outright)
Kentucky is 5-0-1 ATS in its last six meetings with Florida.
Each of Kentucky's past eight games against AP-ranked teams have gone under the total.
Florida is 13-6-1 ATS as an underdog since the start of the 2018 season.
No. 1 Georgia (-16) at Auburn
Saturday, 3:30 p.m. ET, Jordan-Hare Stadium, Auburn, Alabama
Money Line: Georgia (-800); Auburn (+550)
Game Total: 47.5 points
FPI Favorite: Georgia by 13.9 (81.9% chance to win outright)
Georgia has covered each of its past five meetings with Auburn.
Georgia is 12-4 ATS as a road favorite since the start of the 2019 season.
Each of Auburn's last four games against AP-ranked opponents have gone over the total.
No. 2 Michigan (-18) at Nebraska
Saturday, 3:30 p.m. ET, Memorial Stadium, Lincoln, Nebraska
Money Line: Michigan (-1100); Nebraska (+700)
Game Total: 41 points
FPI Favorite: Michigan by 17.8 (87.6% chance to win outright)
Michigan has gone under the total in four consecutive games, tied for the longest active streak in the FBS.
Nebraska is 8-2 ATS in its last 10 games as a double-digit underdog.
No. 24 Kansas at No. 3 Texas (-17)
Saturday, 3:30 p.m. ET, DKR-Texas Memorial Stadium, Austin, Texas
Money Line: Kansas (+600); Texas (-900)
Game Total: 62 points
FPI Favorite: Texas by 24.2 (93.5% chance to win outright)
Kansas is 4-0 ATS against AP-ranked opponents since the start of the 2018 season.
Kansas has covered five of its last six games against Texas.
11 of 13 Kansas road games since the start of the 2021 season have gone over the total.
No. 23 Missouri (-13) at Vanderbilt
Saturday, 4 p.m. ET, FirstBank Stadium, Nashville, Tennessee
Money Line: Missouri (-550); Vanderbilt (+400)
Game Total: 56.5 points
FPI Favorite: Missouri by 12.8 (80.2% chance to win outright)
Vanderbilt is 0-5 ATS this season. The five cover losses are the most of any team in the FBS.
Vanderbilt is 0-5 ATS against AP-ranked teams since the start of last season.
Missouri is 2-8 ATS as a double-digit favorite since the start of the 2021 season.
No. 13 LSU at No. 20 Ole Miss (-3)
Saturday, 6 p.m. ET, Vaught-Hemingway Stadium, Oxford, Mississippi
Money Line: LSU (-140); Ole Miss (+118)
Game Total: 63 points
FPI Favorite: Ole Miss by 2.4 (56.5% chance to win outright)
LSU has gone over the total in eight consecutive games, the longest active over streak in the FBS.
Eight of nine Ole Miss games against AP-ranked opponents have gone under the total since the start of the 2021 season.
Five of the last six meetings between these two teams went over the total.
No. 9 Oregon (-27) at Stanford
Saturday, 6:30 p.m. ET, Stanford Stadium, Stanford, California
Money Line: Oregon (-10000); Stanford (+2000)
Game Total: 61 points
FPI Favorite: Oregon by 30.2 (96.6% chance to win outright)
Oregon is 4-0 ATS this season, the only undefeated ATS team in the Pac-12.
Oregon is 26-13-1 ATS as a road favorite since the start of the 2021 season.
Stanford is 6-20-1 ATS following a straight-up loss since the start of the 2019 season.
Iowa State at No. 14 Oklahoma (-20)
Saturday, 7 p.m. ET, Memorial Stadium, Norman, Oklahoma
Money Line: Iowa State (+800); Oklahoma (+1400)
Game Total: 48.5 points
FPI Favorite: Oklahoma by 25.4 (94.3% chance to win outright)
Oklahoma has covered five consecutive games since the start of last season, tied with Liberty and Penn State for the longest active cover streak in FBS.
Iowa State is 6-0 ATS as a double-digit underdog since the start of the 2017 season.
13 of Iowa State's last 17 games against AP-ranked opponents have gone under the total.
Iowa State hasn't been 20+ point underdogs in a game since 2017.
No. 11 Notre Dame (-5.5) at No. 17 Duke
Saturday, 7:30 p.m. ET, Wallace Wade Stadium, Durham, North Carolina
Money Line: Notre Dame (-205); Duke (+170)
Game Total: 51 points
FPI Favorite: Notre Dame by 7.6 (69.4% chance to win outright)
Each of Duke's past 12 games against AP-ranked opponents have gone under the total.
Duke is 6-1 ATS as a home underdog since the start of last season.
Notre Dame is 5-1 ATS in its last six games as a favorite.
South Carolina at No. 21 Tennessee (-11.5)
Saturday, 7:30 p.m. ET, Neyland Stadium, Knoxville, Tennessee
Money Line: South Carolina (+345); Tennessee (-455)
Game Total: 62 points
FPI Favorite: Tennessee by 8 (70.3% chance to win outright)
Tennessee is 13-5 ATS as a double-digit favorite since the start of the 2020 season.
Each of the past four meetings between South Carolina and Tennessee have gone over the total.
12 of South Carolina's last 16 road games have gone over the total.
No. 12 Alabama (-14.5) at Mississippi State
Saturday, 9 p.m. ET, Davis Wade Stadium, Starkville, Mississippi
Money Line: Alabama (-600); Mississippi State (+430)
Game Total: 48.5 points
FPI Favorite: Alabama by 18 (87.7% chance to win outright)
Alabama has covered five consecutive meetings with Mississippi State.
Mississippi State has failed to cover each of its past four games as a home underdog.
Mississippi State is 1-6 ATS in its last seven SEC games.
No. 7 Washington (-17.5) at Arizona
Saturday, 10 p.m. ET, Arizona Stadium, Tucson, Arizona
Money Line: Washington (-1000); Arizona (+650)
Game Total: 69.5 points
FPI Favorite: Washington by 16.3 (85.6% chance to win outright)
Arizona has gone under the total in four consecutive games, tied for the longest active under streak in the FBS.
Arizona has covered each of its past three games against teams ranked in the AP Top 10.
Washington has covered three consecutive road games.
Washington is 5-1 ATS in its last six games as a favorite.
Nevada at No. 25 Fresno State (-24.5)
Saturday, 10:30 p.m. ET, Bulldog Stadium, Fresno, California
Money Line: Nevada (+1450); Fresno State (-4000)
Game Total: 54.5 points
FPI Favorite: Fresno State by 25.1 (94.2% chance to win outright)
Each of the past four games between Fresno State and Nevada have gone over the total.
Nevada is 9-3 ATS in its last 12 games as a road underdog.
Fresno State is 4-1 ATS in its last five games as a double-digit favorite.