Corona, who has 71 caps for Mexico and has scored 10 goals, suffered a fracture on his left ankle while he was training with Sevilla in August and underwent surgery.
The 29-year-old was named in Mexico coach Gerardo "Tata" Martino's preliminary 31-man squad and the Argentine had been counting on his recovery before the Nov. 20-Dec. 18 tournament in Qatar.
"Tecatito is progressing day by day, his discharge date to return to training with the group is December 1 or 2," Sampaoli told reporters.
"So I do not see him having that possibility [of playing at the World Cup] due to the medical report.
"His evolution is good, but he had a very serious injury, and bringing [his return] forward might be a risk. Here, the ones who determine whether he can be there or not are the medical staff."
Mexico said they will finalise their 26-man squad by Nov. 14, three weeks before Corona is set to return to training.