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College Football Week 4: Betting odds and lines for Top 25 teams

Shedeur Sanders and the No. 18 Colorado Buffaloes enter Saturday afternoon as 20.5-point underdogs to the Oregon Ducks. AP Photo/David Zalubowski

The 2023 college football season moves along to Week 4, featuring a plethora of marquee matchups and ranked showdowns. Saturday's slate begins with No. 4 Florida State facing Clemson with potential ACC title implications on the line. Deion Sanders' No. 18 Colorado Buffaloes head to Eugene take on No. 10 Oregon in a battle of undefeated Pac-12 foes. No. 15 Ole Miss meets No. 13 Alabama as the Rebels look for their first win over the Crimson Tide since 2015. The day of action concludes with an AP-Top 10 game between No. 6 Ohio State and No. 9 Notre Dame.

Here are the betting lines, money lines and totals for Week 4 of the college football season.

All odds are courtesy of Caesars Sportsbook. Football Power Index (FPI) by ESPN Sports Analytics Group.


Rutgers at No. 2 Michigan (-24)
Saturday, 12 p.m. ET, Michigan Stadium, Ann Arbor, Michigan

Money line: Rutgers (+1100); Michigan (-2500)
Total: 44 points
FPI favorite: Michigan by 16 (85% chance to win outright)

Betting nuggets

  • Rutgers is 3-0 ATS this season, one of three teams in the Big Ten to be undefeated ATS along with Indiana and Penn State.

  • Eight of the last nine meetings between Michigan and Rutgers have gone over the total.


No. 4 Florida State (-2) at Clemson
Saturday, 12 p.m. ET on ABC, Memorial Stadium, Clemson, South Carolina

Money line: Florida State (-130); Clemson (+110)
Total: 55 points
FPI favorite: Florida State by 2.8 (57.4% chance to win outright)

Betting nuggets

  • Clemson has covered each of its last five meetings with Florida State.

  • This is the first time that Clemson is a home underdog since Oct. 1, 2016, when it was 1-point underdogs to No. 3 Louisville, a game they won outright.

  • Florida State is one of four ACC teams to go over the total in every game this season, along with Boston College, Georgia Tech and Virginia.


No. 16 Oklahoma (-14.5) at Cincinnati
Saturday, 12 p.m. ET, Nippert Stadium, Cincinnati, Ohio

Money line: Oklahoma (-650); Cincinnati (+460)
Total: 57.5 points
FPI favorite: Oklahoma by 17.3 (86.7% chance to win outright)

Betting nuggets

  • Oklahoma is 3-0 ATS this season, the only team in the Big 12 that is undefeated ATS.

  • Cincinnati is 1-5 ATS as an underdog since the start of the 2021 season.

  • Each of Cincinnati's past five games following a straight-up loss have gone under the total.


No. 19 Colorado at No. 10 Oregon (-21)
Saturday, 3:30 p.m. ET on ABC, Autzen Stadium, Eugene, Oregon

Money line: Colorado (+600); Oregon (-950)
Total: 70.5 points
FPI favorite: Oregon by 24.9 (93.9% chance to win outright)

Betting nuggets

  • Colorado won outright against TCU as 21-point underdogs earlier this season. Only 3 teams have won multiple games as an underdog of 20-plus points in a season since the FBS/FCS split in 1978: 1982 Northwestern, 2021 UL Monroe and 2022 Georgia Tech.

  • Colorado has gone over the total in each of its seven road games since the start of last season.


No. 22 UCLA at No. 11 Utah (-5)
Saturday, 3:30 p.m. ET, Rice-Eccles Stadium, Salt Lake City, Utah

Money line: UCLA (+162); Utah (-195)
Total: 52.5 points
FPI favorite: Utah by 6 (65.5% chance to win outright

Betting nuggets

  • Utah has gone under the total in each of its three games this season.

  • Utah has covered five of its last six games against UCLA.

  • UCLA has covered nine of its last 12 road games.


No. 15 Ole Miss at No. 13 Alabama (-7)
Saturday, 3:30 p.m. ET, Bryant-Denny Stadium, Tuscaloosa, Alabama

Money line: Ole Miss (+215); Alabama (-267)
Total: 55.5 points
FPI favorite: Alabama by 6.2 (66% chance to win outright)

Betting nuggets

  • Ole Miss is 3-0 ATS this season, the only team in the SEC that is undefeated ATS.

  • The under is 7-1 in eight Ole Miss games against AP-ranked opponents since the start of the 2021 season.

  • Nick Saban is 1-3 ATS against Lane Kiffin (4-0 outright).


No. 18 Duke (-21.5) at UConn
Saturday, 3:30 p.m. ET, Pratt & Whitney Stadium, East Hartford, Connecticut

Money line: Duke (-1700); UConn (+950)
Total: 45.0 points
FPI favorite: Duke by 23.1 (92.6% chance to win outright)

Betting nuggets

  • UConn has gone under the total in each of its three games this season.

  • UConn has covered each of its past four games as a home underdog.

  • Duke is 5-12 ATS on the road since the start of the 2020 season.


No. 20 Miami (-24.0) at Temple
Saturday, 3:30 p.m. ET on ESPN2, Lincoln Financial Field, Philadelphia, Pennsylvania

Money line: Miami (-1700), Temple (+950)
Total: 49.0 points
FPI favorite: Miami by 26.7 (94.9% chance to win outright)

Betting nuggets

  • Temple has failed to cover each of its past four games against AP-ranked opponents.

  • Temple is 7-13 ATS as a double-digit underdog since the start of the 2019 season.

  • Miami is 5-12 ATS as a favorite since the start of the 2021 season.


UTSA at No. 23 Tennessee (-21)
Saturday, 4 p.m. ET, Neyland Stadium, Knoxville, Tennessee

Money line: UTSA (+800); Tennessee (-1400)
Total: 59.0 points
FPI favorite: Tennessee by 17.1 (86.4% chance to win outright)

Betting nuggets.

  • Tennessee is 6-1 ATS following a straight-up loss since the start of the 2021 season.

  • UTSA has failed to cover in each of its three games this season.


Arkansas at No. 12 LSU (-17.5)
Saturday, 7 p.m. ET on ESPN, Baton Rouge, Louisiana

Money line: Arkansas (+600); LSU (-900)
Total: 55.0 points
FPI favorite: LSU by 18.7 (88.4% chance to win outright)

Betting nuggets

  • LSU is 4-0 ATS as a home favorite since the start of last season.

  • LSU is 5-1 ATS as a double-digit favorite since the start of last season.

  • All four of Arkansas' road games have gone over the total since the start of last season.


No. 14 Oregon State (-3) at No. 21 Washington State
Saturday, 7 p.m. ET, Martin Stadium, Pullman, Washington

Money line: Oregon State (-145); Washington State (+122)
Total: 57.5 points
FPI favorite: Oregon State by 6 (65.6% chance to win outright)

Betting nuggets

  • Oregon State is 10-2 ATS as a favorite since the start of last season, the best such cover percentage in the Pac-12 over that span.

  • Washington State is 5-1 ATS in its last six games as a home underdog.

  • Eight of the past 10 meetings between Oregon State and Washington State have gone over the total.


Charlotte at No. 25 Florida (-28)
Saturday, 7 p.m. ET on SEC Network, Ben Hill Griffin Stadium, Gainesville, Florida

Money line: Florida (-7000), Charlotte (+1800)
Total: 49 points
FPI favorite: Florida by 27.4 (95.3% chance to win outright)

Betting nuggets

  • Florida is 4-15 ATS as a favorite since the start of the 2021 season.

  • Florida is 3-9 ATS against non-conference opponents since the start of the 2021 season.

  • Six of Charlotte's last seven September games have gone over the total.


UAB at No. 1 Georgia (-42)
Saturday, 7:30 p.m. ET on ESPN2, Sanford Stadium, Athens, Georgia

Total: 54.0 points
FPI favorite: Georgia by 38.1 (98.6% chance to win outright)

Betting nuggets

  • UAB is 0-7 ATS in road games since the start of last season.

  • All three of Georgia's games this season have gone under the total.


No. 3 Texas (-15) at Baylor
Saturday, 7:30 p.m. ET on ABC, McLane Stadium, Waco, Texas

Money line: Texas (-650), Baylor (+460)
Total: 51.5 points
FPI favorite: Texas by 20.4 (90.2% chance to win outright)

Betting nuggets

  • All five Texas road games have gone over the total since the start of last season.

  • Baylor is 3-0 ATS against AP Top-5 teams since the start of the 2021 season.

  • Baylor is 12-4-1 ATS as a home underdog since the start of the 2011 season.

  • Baylor is 9-3 ATS against AP Top-10 teams since the start of the 2017 season.


No. 6 Ohio State (-3) at No. 9 Notre Dame
Saturday, 7:30 p.m. ET, Notre Dame Stadium, Notre Dame, Indiana

Money line: Ohio State (-160); Notre Dame (+135)
Total: 55.5 points
FPI favorite: Ohio State by 6.1 (65.9% chance to win outright)

Betting nuggets

  • Notre Dame is 6-1 outright and ATS as a home underdog in the last 10 seasons.

  • Ohio State is 0-4 ATS in its past four games as a road favorite.


No. 24 Iowa at No. 7 Penn State (-15)
Saturday, 7:30 p.m. ET, Beaver Stadium, University Park, Pennsylvania

Money line: Iowa (+460); Penn State (-650)
Total: 40 points
FPI favorite: Penn State by 17.5 (87% chance to win outright)

Betting nuggets

  • Penn State is 3-0 ATS this season and 7-2-1 ATS in Big Ten games since the start of last season

  • Iowa has failed to cover each of its past three games against AP Top-10 opponents.


No. 17 North Carolina (-7.5) at Pittsburgh
Saturday, 8 p.m. ET on ACC Network, Acrisure Stadium, Pittsburgh, Pennsylvania

Money line: North Carolina (-305); Pittsburgh (+240)
Total: 50 points
FPI favorite: North Carolina by 5.2 (63.5% chance to win outright)

Betting nuggets

  • North Carolina is 12-3 ATS in its past 15 games against Pittsburgh.

  • North Carolina is 1-6-1 ATS as a road favorite since the start of the 2020 season.

  • Pittsburgh is 1-5 ATS as an underdog since the start of the 2021 season.

  • Nine of Pittsburgh's past 11 September games have gone over the total.


No. 5 USC (-33.5) at Arizona State
Saturday, 10:30 p.m. ET, Mountain America Stadium, Tempe, Arizona

Money line: USC (-80000); Arizona State (+2750)
Total: 62 points
FPI favorite: USC by 35.5 (98.1% chance to win outright)

Betting nuggets

  • Arizona State is 0-3 ATS this season, the only winless team ATS in the Pac-12.

  • Arizona State has covered each of its past three games against USC.

  • USC is 0-4 ATS following a bye week since the start of the 2021 season.

  • Four of USC's five road games have gone over the total since the start of last season.


California at No. 8 Washington (-21)
Saturday, 10:30 p.m. ET on ESPN, Husky Stadium, Seattle, Washington

Money line: California (+700); Washington (-1100)
Total: 59.5 points
FPI favorite: Washington by 15.7 (84.5% chance to win outright)

  • California has covered its last four meetings against Washington.

  • California is 13-4 ATS as a road underdog since the start of the 2018 season.

  • Washington has covered four of its last five games as a favorite.