Osemele was injured without being hit. He stumbled on the turf after trying to block on a Patrick Mahomes scramble. He was taken off the field on a cart.
The Chiefs also lost wide receiver Sammy Watkins in the second quarter with a hamstring injury. Watkins hobbled off the field and after a quick sideline examination left for the locker room. He didn't return to the sideline.
Before the injury, Watkins had two catches for 24 yards and a touchdown.