Bold prediction: Both Chubb (141 yards) and Houston RB Dameon Pierce (139) will rush for season highs. This season, Pierce is averaging 4.4 yards per carry and Chubb is averaging 5.2. -- Jake Trotter
Stat to know: The Browns have won two straight against the Texans (2020, 2021). Cleveland has never won three straight in the series (5-7 all-time record).
Injuries: Browns | Texans
What to know for fantasy: Over the past two weeks, Pierce is averaging less than one foot per carry before contact. One foot, not one yard. See Week 13 rankings.
Betting nugget: Quarterbacks who have not started a game in 500 or more days and are laying at least seven points in their first start after the layoff are 1-6 ATS in the past 25 seasons, including 1-3 outright and ATS in the past 15 seasons. Read more.
Moody's pick: Browns 30, Texans 14
Walder's pick: Browns 20, Texans 16
FPI prediction: CLE, 78.8% (by an average of 9.4 points)
Matchup must-reads: Watson silent, but Browns teammates talk buzz of return ... 2023 projected NFL draft order: Texans looking at the No. 1 pick? ... Some women who settled lawsuits vs. Watson to attend game
Jaguars (4-7) at Lions (4-7)
1 p.m. ET | Fox | Spread: JAX -1 (51.5)
What to watch for: After a Thanksgiving Day loss to Buffalo, the Lions, who have won three of their past four, return home to host the Jaguars. Jacksonville is looking to build off a come-from-behind victory against the Ravens last Sunday. The No. 1 (Jaguars' LB Travon Walker) and No. 2 (Lions' DE Aidan Hutchinson) overall picks from the 2022 draft will share the field for the first time. -- Eric Woodyard
Bold prediction: The teams will combine for more than 900 yards of offense. The Lions have the league's worst defense (414.5 yards and 28.2 points per game allowed) and Jaguars QB Trevor Lawrence is on a roll. He has thrown six TDs, no interceptions and topped 100 in passer rating in his past three games. The Jaguars struggle to get pressure (17 sacks) on defense and Lions QB Jared Goff will post his third 300-yard passing game of the season. -- Mike DiRocco
Stat to know: The Jaguars have lost 19 straight vs. NFC teams, and the Lions are winless in the past 11 games vs. AFC teams (0-10-1). These are two of the longest active winless streaks against teams in opposing conferences.
Injuries: Jaguars | Lions
What to know for fantasy: Jamaal Williams hasn't caught a pass (or averaged even 4.0 yards per carry) in four straight games, but he has masked a lack of versatility with five rushing scores over his past three games. See Week 13 rankings.
Betting nugget: Jacksonville has failed to cover its past seven games as a favorite, including 0-3 ATS this season and 0-6 ATS since 2020. Read more.
Moody's pick: Jaguars 31, Lions 27
Walder's pick: Jaguars 28, Lions 22
FPI prediction: JAX, 59.0% (by an average of 2.7 points)
Matchup must-reads: Jaguars QB Lawrence after comeback win: 'I've always been this guy' ... How top picks Walker, Hutchinson are doing in the NFL
Dolphins (8-3) at 49ers (7-4)
1:05 p.m. ET | Fox | Spread: SF -4 (46.5)
What to watch for: Miami coach Mike McDaniel returns to San Francisco to face the Niners and coach Kyle Shanahan for the first time after the pair coached together for 14 years at various stops. These teams run the same offense but in vastly different ways. This matchup pits the Dolphins' blazing speed against the Niners' brute force. Both styles work well as Miami is third and San Francisco is sixth in the NFL in yards per play, which means this game could come down to which defense can create more opportunities for its offense. -- Nick Wagoner
Bold prediction: A 49ers defense that has allowed a league-low 46 explosive plays will give up three to Miami, including a pair of long touchdowns to Tyreek Hill and Jaylen Waddle. Tua Tagovailoa will be unphased throwing in rainy weather, becoming the second player this season to throw for 300 yards against this San Francisco defense. -- Marcel Louis-Jacques
Stat to know: The Dolphins have won five straight and the 49ers have won four consecutive games. The home team has won nine of the past 10 meetings between teams entering on four-game winning streaks with the average point differential being plus-17.4.
Injuries: Dolphins | 49ers
What to know for fantasy: Brandon Aiyuk has at least seven targets or has scored a touchdown in six straight games. See Week 13 rankings.
Betting nugget: Over the past five seasons, teams with at least a .700 winning percentage are 17-6 ATS when getting at least 3.5 points in games in November or later. They are 15-4 ATS when removing Week 17 games. Read more.
Moody's pick: 49ers 34, Dolphins 21
Walder's pick: Dolphins 26, 49ers 20
FPI prediction: SF, 65.2% (by an average of 4.5 points)
Matchup must-reads: Dolphins confident Terron Armstead (pec) will return this season ... How the Dolphins and 49ers run similar offenses in different ways ... 'Disappointed' Mitchell out for 49ers with sprained MCL
Seahawks (6-5) at Rams (3-8)
4:05 p.m. ET | Fox | Spread: SEA -7.5 (41)
What to watch for: Although the Seahawks are 1-7 in road games against the Rams dating back to 2014, with a win on Sunday, Seattle has the chance to ensure Los Angeles finishes this season with a losing record. With one more loss, the Rams would be the first team since the 2003 Buccaneers (7-9) to have a losing record the season after winning the Super Bowl. -- Sarah Barshop
Bold prediction: Tyler Lockett will top 100 yards receiving and score a touchdown. With DK Metcalf figuring to get plenty of attention from All-Pro cornerback Jalen Ramsey, in addition to his usual amount of double teams, Lockett should see some favorable matchups. And with no Aaron Donald there to collapse the pocket, Geno Smith should have the time he needs to find Lockett on a deep shot or two. -- Brady Henderson
Stat to know: Smith has thrown multiple passing touchdowns in five straight games, which is the longest streak of his career and the longest active streak in the NFL.
Injuries: Seahawks | Rams
What to know for fantasy: Kenneth Walker III has been a scoring machine (nine rushing scores in his past seven games), but he's been held to under 3.0 yards per carry in three of his past four, giving him a lower floor than other elite backs. See Week 13 rankings.
Betting nugget: Los Angeles is a league-worst 2-8-1 ATS this season, including 0-4-1 ATS as an underdog, 1-5 ATS at home and 0-5 ATS against teams with winning records. Read more.
Moody's pick: Seahawks 30, Rams 20
Walder's pick: Seahawks 23, Rams 20
FPI prediction: SEA, 65.8% (by an average of 5.1 points)
Matchup must-reads: Can Seahawks avoid rookie wall in crucial final six games? ... Donald to miss first game due to injury ... Seahawks' defense threatens playoff hopes amid another slump ... Rams identifying long-term contributors
Chiefs (9-2) at Bengals (7-4)
4:25 p.m. ET | CBS | Spread: KC -1.5 (52.5)
What to watch for: The rematch of the AFC Championship Game features two of the league's top offenses. Chiefs QB Patrick Mahomes and Bengals QB Joe Burrow are first and second, respectively, in the NFL in passing touchdowns. And Kansas City leads the league in points per drive while the Bengals are fourth. -- Ben Baby
Bold prediction: The Chiefs will sack Burrow four times. The Chiefs got him only once in last year's AFC Championship Game, this in between the Bengals allowing nine sacks to the Titans and seven to the Rams. But the Chiefs' pass rush is far more productive this season -- they are fifth in the league with 35 sacks and have 21 sacks in the last five games. Cincinnati has allowed 35 sacks, fifth most in the league this season. -- Adam Teicher
Stat to know: Mahomes is 1-2 in his career against the Bengals, including the playoffs, with both losses coming last season (he has never lost three games to the same opponent). His 85 career starts, including the playoffs, without losing three games vs. the same opponent is the furthest into a quarterback's career since 1950.
Injuries: Chiefs | Bengals
What to know for fantasy: Tee Higgins has gone over 100 receiving yards in consecutive games (without Ja'Marr Chase active) after reaching triple figures just once in his first nine games this season. See Week 13 rankings.
Betting nugget: Cincinnati has covered six straight games as an underdog dating back to last season, including the playoffs. Read more.
Moody's pick: Chiefs 30, Bengals 27
Walder's pick: Chiefs 27, Bengals 24
FPI prediction: KC, 56.7% (by an average of 2.1 points)
Matchup must-reads: Chiefs QB Mahomes and wife welcome son ... Chase says he didn't play Bengals-Titans as precaution ... Sources: DT Williams to sign with Chiefs' practice squad ... Gordon says he's signing on to Chiefs' practice squad
Chargers (6-5) at Raiders (4-7)
4:25 p.m. ET | CBS | Spread: LV -1.5 (50.5)
What to watch for: The Chargers are giving up 5.4 yards per carry, the worst in a single season in the Super Bowl era. Raiders RB Josh Jacobs is coming off his tour de force in Seattle, where 229 of his 303 all-purpose yards and both of his TDs came on the ground. So, Las Vegas should run well against the Chargers, right? Well, Jacobs has averaged only 73.5 yards per game and 4.2 yards per carry in six games against the Chargers, and he is nursing a strained left calf that had him a game-time decision before last week's show. -- Paul Gutierrez
Bold prediction: Jacobs will turn in a 100-yard performance against the Chargers -- despite rushing for only 57 yards against the Bolts in Week 1. The Raiders ended the Chargers' hope of a playoff appearance with an overtime victory in Week 18 last season, but Bolts coach Brandon Staley said that not-so-distant memory "will have zero impact on the game" on Sunday. What will have an impact? The Chargers' porous run defense allows an average of 151.4 yards per game (which ranks 28th). -- Lindsey Thiry
Stat to know: Justin Herbert has thrown 13 touchdowns and one interception in his career against the Raiders (3-2 record). He has thrown at least two passing TDs in five straight games against the Raiders, which is tied for the second-longest streak against the Raiders in team history (Dave Krieg had seven straight).
Injuries: Chargers | Raiders
What to know for fantasy: Austin Ekeler scored 25 fantasy points last week in Arizona, the sixth time he's racked up at least 24 points in a game this season (tied for the most among all flex players). See Week 13 rankings.
Betting nugget: Las Vegas has covered three straight games as an underdog. The Raiders are 3-1 ATS as an underdog this season and 2-5 ATS as a favorite. This is their first game as a home underdog since last year's Week 18 matchup against the Chargers (Raiders won by three as 3-point home underdogs). Read more.
Moody's pick: Chargers 34, Raiders 27
Walder's pick: Raiders 30, Chargers 27
FPI prediction: LV, 61.9% (by an average of 3.4 points)
Matchup must-reads: Where Herbert lands on our Top 25 Under 25 ... Raiders players maintaining faith in Josh McDaniels despite slow start
Colts (4-7-1) at Cowboys (8-3)
8:20 p.m. ET | NBC | Spread: DAL -11 (43.5)
What to watch for: Coming off a difficult three-game stretch in 12 days, it might look like the Cowboys can take a breather in their next three games against sub-.500 AFC South foes, starting Sunday with the Colts. But Mike McCarthy knows the importance of December football. McCarthy has a 42-18 record in December as a head coach. The Cowboys lead the NFL with 45 sacks, which might make life for Matt Ryan difficult since he has been sacked 32 times in 10 games. -- Todd Archer
Bold prediction: Running back Jonathan Taylor will rush for 150 yards or more against a Dallas defense that twice this season has allowed teams to run for more than 200 yards. It might not be enough to score a win, but the Colts have an opportunity to exploit an inconsistent Cowboys run defense. Taylor has battled injuries this season, but he's averaged five yards per carry in his past five games after posting a four-yard per-carry average in his first four. -- Stephen Holder
Stat to know: The Colts have not won at Dallas since Week 3 in 1996. The Colts are winless in two games at Dallas since that 1996 victory; they join the Chiefs (0-2), Texans (0-2) and Bengals (0-4) as the only teams who have not beaten Dallas on its home field since 1997.
Injuries: Colts | Cowboys
What to know for fantasy: As good as Tony Pollard looks, fantasy is a game of production and having scored in each of his past four games, Ezekiel Elliott continues to hold value. See Week 13 rankings.
Betting nugget: Dallas is an NFL-best 20-8 ATS since the start of last season, including 14-5 ATS as a favorite. Read more.
Moody's pick: Cowboys 30, Colts 13
Walder's pick: Cowboys 34, Colts 20
FPI prediction: DAL, 88.0% (by an average of 14.1 points)
Matchup must-reads: Colts' Jeff Saturday says he wishes he had used late timeout ... Giants, Cowboys or Bills: Where will Odell Beckham Jr. land? ... OBJ free agency: Cowboys, Bills, Giants stars entice WR ... Is NFC East the NFL's best division?
Saints (4-8) at Buccaneers (5-6)
Monday, 8:15 p.m. ET | ESPN | Spread: TB -4.0 (40.5)
What to watch for: The Bucs were expected to run away with the NFC South in 2022, but losing to the Browns in Week 12 opened the door for the Saints. This game has meaningful potential in the standing. Making matters worse for Tampa Bay, All-Pro right tackle Tristan Wirfs is out with a high ankle sprain, and the Bucs' defense is struggling to put together complete games while the offense can't seem to clear the 17-point threshold recently. -- Jenna Laine
Bold prediction: The Saints will win a low-scoring game like their 9-0 victory in Tampa Bay last season. The Saints' offense has struggled a lot this year and was shut out last week, but there have been some positive signs from the defense lately, which has mostly had Tom Brady's number in the past few years. If Marshon Lattimore returns, expect another solid performance against Brady, especially considering the Bucs have struggled on offense. -- Katherine Terrell
Stat to know: Tom Brady is 1-4 against the Saints in the regular season since joining the Buccaneers in 2020, with the lone win coming this season. In four of those five games, Brady has posted his lowest total QBR against any single opponent since signing with Tampa Bay, and that includes the win this season which was a season low.
Injuries: Saints | Buccaneers
What to know for fantasy: Mike Evans has been held under 13 fantasy points in eight straight meetings with the Saints and enters this game having failed to score even 11 fantasy points in three straight. See Week 13 rankings.
Betting nugget: New Orleans is 0-5 ATS on the road this season. Read more.
Moody's pick: Buccaneers 21, Saints 16
Walder's pick: Buccaneers 23, Saints 13
FPI prediction: TB, 62.1% (by an average of 3.5 points)
Matchup must-reads: Saints would throw NFC South into chaos with win at Buccaneers ... Source: Bucs' Wirfs (high ankle sprain) out weeks