Chiefs (5-1) at Broncos (2-3)
4:25 p.m. ET | CBS
Matchup rating: 74.3 | Spread: KC -10 (46)
What to watch for: Will the Broncos make rushing yards matter? The best, and perhaps only, defense against Chiefs quarterback Patrick Mahomes is keeping the ball away from him. The idea that you can pound away to win can be a tough sell, but the Chiefs have not defended the run well much of the season. They've allowed at least 144 rushing yards four times and over 180 yards twice -- but have lost just one of those games. Snow could be in the forecast, and the Broncos' best chance to win will be a run game paired with some play-action shots down the field. -- Jeff Legwold
Bold prediction: The Broncos will score multiple touchdowns. OK, that might not sound like a bold prediction, but they haven't scored even one in their past seven quarters against the Chiefs. -- Adam Teicher
Stat to know: Mahomes has had multiple passing touchdowns in each of the first six games of the season, making him the first Chief in history to do so.
What to know for fantasy: What will Chiefs running back Le'Veon Bell's impact be? Clyde Edwards-Helaire is RB16 on a per-game basis thus far, and if he loses 20% of his value to Bell, he'd fall to RB26. See Week 7 rankings.
Betting nugget: Denver is 4-1 ATS as an underdog this season. Read more.
Teicher's pick: Chiefs 31, Broncos 23
Legwold's pick: Chiefs 27, Broncos 22
FPI prediction: KC, 75.9% (by an average of 9.6 points)
Matchup must-reads: Chiefs can't wait to add Bell to a loaded offensive lineup ... Why Broncos' Lock needs to learn to play it safe sometimes ... Why have the Chiefs pumped the brakes on Hardman? ... Much-maligned Broncos tackle Bolles is ... good now?