4:25 p.m. ET | FOX
Matchup rating: 59.2 | Spread: NO -5 (43.5)
What to watch for: The Bears seemed to be in shambles after Monday night's debacle in Los Angeles. All is lost, right? Not so fast. Looks can be deceiving, particularly when it pertains to the Bears. But since coach Matt Nagy took over in 2018, the Bears are 8-4 following a loss, and more importantly, 5-0 on short weeks. The Bears are often at their best when expectations are at their lowest. -- Jeff Dickerson
Bold prediction: Chicago quarterback Nick Foles will bounce back from Monday night's dud with at least one deep touchdown pass. The Saints have now allowed six passes of 48-plus yards in their past four games. But the Saints will see running backs Alvin Kamara and Latavius Murray combine for 150 rushing yards. -- Mike Triplett
Stat to know: The Saints' 78.7 offensive efficiency is sixth in the NFL, but their 23.2 defensive efficiency ranks 28th. No team has made the playoffs with a defensive efficiency below 30 since efficiency ratings began in 2006.
What to know for fantasy: Kamara is looking to join Saquon Barkley, Todd Gurley II and DeMarco Murray as the only non-QBs since 2001 to open a season with 19.9 fantasy points in each of their teams' first seven games. See Week 8 rankings.
Betting nugget: New Orleans is 14-4 ATS on the road since the start of the 2018 season. Read more.
Triplett's pick: Saints 27, Bears 23
Dickerson's pick: Bears 23, Saints 21
FPI prediction: NO, 61.5% (by an average of 4.0 points)
Matchup must-reads: Brees, Saints still have that two-minute-drill magic ... Sizing up the NFC North: Who's surprising, disappointing and more ... Former LB Briggs channels inner superhero with new graphic novel