Packers (4-0) at Buccaneers (3-2)
4:25 p.m. ET | Fox
Matchup rating: 85.0 | Spread: GB -1.5 (55)
What to watch for: The Bucs are hopeful that Tom Brady can get back some of his weapons, such as wide receiver Chris Godwin and running back Leonard Fournette, along with a healthier Scotty Miller and Mike Evans. But the big question is how they'll replace 347-pound defensive tackle Vita Vea, who was a key reason the Buccaneers have had the league's top-ranked rushing defense over the past two years and why their pass rush has improved to be among the best. Who will try to rattle Packers quarterback Aaron Rodgers now? -- Jenna Laine
Bold prediction: The Packers' defense will finally make a stand. Aaron Rodgers & Co. have carried the team to a 4-0 start, but after a bye week to figure out what has gone wrong, Mike Pettine's defense will find a way to come up big. Look for the Smiths (Preston Smith and Za'Darius Smith) to have success against the statuesque Brady, and Kenny Clark's return will help a run defense that so far has allowed nearly 5 yards per carry. -- Rob Demovsky
Stat to know: The Packers' 93.3 offensive efficiency is the second highest through four team games since 2008 (95 by the Rams in 2018). And per the Elias Sport Bureau, Green Bay now has four consecutive games scoring at least 30 points with zero turnovers, tied for the second-longest streak in NFL history (2010 Patriots, seven straight).
Injuries: Packers | Buccaneers
What to know for fantasy: Tampa Bay running back Ronald Jones is the only player in the NFL this season with multiple games of 100 rushing yards and five targets. See Week 6 rankings.
Betting nugget: Green Bay is 4-0 ATS, making it the only undefeated team ATS left this season. Read more.
Demovsky's pick: Packers 27, Buccaneers 24
Laine's pick: Buccaneers 31, Packers 27
FPI prediction: TB, 53.0% (by an average of 1.1 points)
Matchup must-reads: One night in Atlanta 10 years ago, Rodgers became a star ... Brady pokes fun at himself while congratulating LeBron ... Brady's fourth-down gaffe joins list of other interesting errors with time and turnovers