Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the Expected XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All Expected XIs and injury news powered by Rotowire, subject to updates.)
Chelsea v Aston Villa
Stamford Bridge
Sunday, 8.30 a.m. ET / 1.30 p.m. UK
Latest Chelsea team news
Expected Lineup:
GK Robert Sánchez
LB Marc Cucurella | CB Levi Colwill | CB Wesley Fofana | RB Malo Gusto
DM Moisés Caicedo | DM Enzo Fernández
LW João Félix | AM Cole Palmer | RW Noni Madueke
ST Nicolas Jackson
Injury/suspension updates:
Malo Gusto, D, illness, DOUBT
Reece James, D, hamstring, OUT, estimated return Jan. 4
Pedro Neto, F/M, undisclosed, DOUBT
Latest Aston Villa team news
Expected Lineup:
GK Emiliano Martínez
LB Ian Maatsen | CB Diego Carlos | CB Pau Torres | RB Ezri Konsa
DM Ross Barkley | DM Youri Tielemans
LW John McGinn | AM Morgan Rogers | RW Leon Bailey
ST Ollie Watkins
Injury/suspension updates:
Amadou Onana, M, undisclosed, DOUBT
Jacob Ramsey, M, hamstring, OUT, estimated return Dec. 14
Manchester United v Everton
Old Trafford
Sunday, 8.30 a.m. ET / 1.30 p.m. UK
Latest Manchester United team news
Expected Lineup:
GK André Onana
CB Matthijs de Ligt | CB Lisandro Martínez | CB Noussair Mazraoui
LM Diogo Dalot | CM Christian Eriksen | CM Manuel Ugarte | RM Amad Diallo
AM Alejandro Garnacho | AM Bruno Fernandes
ST Marcus Rashford
Injury/suspension updates:
Jonny Evans, D, undisclosed, DOUBT
Victor Lindelöf, D, groin, OUT, estimated return Dec. 1
Harry Maguire, D, calf, OUT, estimated return Dec. 1
Leny Yoro, D, foot, OUT, estimated return Dec. 7
Latest Everton team news
Expected Lineup:
GK Jordan Pickford
LB Vitaliy Mykolenko | CB Jarrad Branthwaite | CB James Tarkowski | RB Ashley Young
DM Abdoulaye Doucouré | DM Idrissa Gueye
LW Iliman Ndiaye | AM Dwight McNeil | RW Jesper Lindstrom
ST Dominic Calvert-Lewin
Injury/suspension updates:
Armando Broja, F, ankle, DOUBT
Seamus Coleman, D, hamstring, OUT, estimated return Dec. 4
James Garner, M, back, OUT, estimated return Dec. 29
Tim Iroegbunam, M, foot, OUT, estimated return Dec. 29
Youssef Chermiti, F, foot, OUT, estimated return Dec. 26
Tottenham Hotspur v Fulham
Tottenham Hotspur Stadium
Sunday, 8.30 a.m. ET / 1.30 p.m. UK
Latest Tottenham Hotspur team news
Expected Lineup:
GK Fraser Forster
LB Destiny Udogie | CB Ben Davies | CB Radu Dragusin | RB Pedro Porro
CM James Maddison | CM Yves Bissouma | CM Pape Matar Sarr
FWL Son Heung-Min | ST Dominic Solanke | FWR Dejan Kulusevski
Injury/suspension updates:
Rodrigo Bentancur, M, suspension, due back Dec. 26
Richarlison, F, hamstring, OUT, estimated return Dec. 15
Mikey Moore, F/M, illness, OUT, estimated return Dec. 12
Wilson Odobert, F/M, hamstring, OUT, estimated return Feb. 15
Cristian Romero, D, foot, DOUBT
Micky van de Ven, D, hamstring, OUT, estimated return Dec. 26
Guglielmo Vicario, G, ankle, OUT, estimated return Feb. 25
Latest Fulham team news
Expected Lineup:
GK Bernd Leno
LB Antonee Robinson | CB Calvin Bassey | CB Issa Diop | RB Kenny Tete
DM Sasa Lukic | DM Andreas Pereira
LW Reiss Nelson | AM Emile Smith Rowe | RW Alex Iwobi
ST Raúl Jiménez
Injury/suspension updates:
Joachim Andersen, D, calf, OUT, estimated return Dec. 22
Sander Berge, M, illness, DOUBT
Jorge Cuenca, D, undisclosed, OUT, estimated return Dec. 5
Harrison Reed, M, knee, OUT, estimated return Dec. 29
Carlos Vinícius, F, undisclosed, DOUBT
Liverpool v Manchester City
Anfield
Sunday, 11:00 a.m. ET / 4 p.m. UK
Latest Liverpool team news
Expected Lineup:
GK Caoimhín Kelleher
LB Andrew Robertson | CB Joe Gomez | CB Virgil van Dijk | RB Trent Alexander-Arnold
DM Ryan Gravenberch | DM Alexis Mac Allister
LW Cody Gakpo | AM Dominik Szoboszlai | RW Mohamed Salah
ST Darwin Núñez
Injury/suspension updates:
Alisson Becker, G, hamstring, OUT, estimated return Dec. 1
Conor Bradley, D, hamstring, DOUBT
Federico Chiesa, F/M, undisclosed, OUT, estimated return Dec. 7
Diogo Jota, F, upper body, OUT, estimated return Dec. 4
Ibrahima Konaté, D, foot, OUT, estimated return Jan. 14
Kostas Tsimikas, D, ankle, OUT, estimated return Dec. 1
Latest Manchester City team news
Expected Lineup:
GK Ederson
LB Josko Gvardiol | CB Manuel Akanji | CB Nathan Aké | RB Kyle Walker
DM Matheus Nunes | DM Rico Lewis
LW Phil Foden | AM Kevin De Bruyne | RW Savinho
ST Erling Haaland
Injury/suspension updates:
Oscar Bobb, F/M, leg, OUT, estimated return Jan. 14
Rúben Dias, D, calf, DOUBT
Jérémy Doku, F/M, quadriceps, DOUBT
Rodri, M, knee, OUT, estimated return Jul. 1
Mateo Kovacic, M, undisclosed, OUT, estimated return Dec. 15
John Stones, D, undisclosed, DOUBT