Our panel of NFL Insiders predict Week 1's biggest upsets, fantasy flops and potential sleepers.
Plus: Which team will be the first to make a quarterback change? How will Odell Beckham Jr. fare against Jalen Ramsey? And which young quarterback would you start your franchise with?
What's your top upset pick for Week 1?
Matt Bowen, NFL writer: Chiefs (+3.5) over Chargers. I'll take the Chiefs on the road here given the offensive game plan I expect to see with Patrick Mahomes under center. Look for Andy Reid to dress this thing up, too. More movement and play-action, and the vertical throws that put stress on the Chargers' three-deep zone coverage. This is about execution for Mahomes and the Chiefs when they have the ball in scoring position to grab the AFC West win.
Dan Graziano, national NFL writer: Falcons (+2) over Eagles. Yeah, I think Atlanta rolls in there Thursday night and knocks off the champs, just as Kansas City did to New England in last year's opener. The Eagles are in rough shape on offense from a health standpoint and might need a couple of weeks to get themselves together, while Atlanta looks healthy and primed for a big season.