The injury occurred when Brown tried to brace himself as he fell after Ravens guard Ben Powers clipped him during a 1-yard run by J.K. Dobbins. Powers was penalized for clipping on the play. Brown had three tackles and one tackle for a loss in 31 snaps on defense before he was injured.
Brown, 25, leads the Titans with 76 tackles this season. Playing in a contract year, he is set to become a free agent after this season.
The Titans selected Brown in the fifth round of the 2017 NFL draft.
Brown's normal backup, David Long, is currently on the reserve/COVID-19 list and not available to play.
The Titans inserted inside linebacker Will Compton to the lineup to take Brown's place. Compton was elevated from the practice squad on Saturday.