Week 3 of the NFL preseason was tough on tight ends, as both the Giants and the Lions suffered setbacks Friday.

Here are the most important injuries that occurred in the third week of preseason games:

Jacksonville Jaguars

WR Marqise Lee (knee)

Prognosis: Lee was carted off with a left knee injury when he was tackled by Falcons safety Damontae Kazee in the first quarter Saturday. Lee is the Jaguars' most experienced receiver, with 171 catches for 2,166 yards and eight touchdowns in four seasons with Jacksonville. "Obviously it looked bad," coach Doug Marrone said after the game. "Doctors told me, 'Hey listen, we're not going to be able to know anything until tomorrow and we'll have more information tomorrow on it.'" -- Michael DiRocco

Tennessee Titans

LB Harold Landry (ankle)

Prognosis: The Titans' second-round pick did not return after suffering an ankle injury early in Saturday's game. -- Turron Davenport

San Francisco 49ers

LB Reuben Foster (concussion)

Prognosis: Foster left with a concussion in the third quarter Saturday against the Colts and did not return. Foster is suspended the first two games of the regular season but was a candidate to play in the preseason finale Thursday. That's almost certainly not going to happen now.

DB Jimmie Ward (quadriceps)

Prognosis: Ward was injured in the first half and did not return to the game. Injuries have been a consistent issue for Ward for most of his career, and this one comes as he enters the last year of his contract. Ward's salary of more than $8 million is fully guaranteed for 2018, and though he's not expected to start, the 49ers need him healthy given his versatility and some of the other question marks they have in their secondary. -- Nick Wagoner

Pittsburgh Steelers

TE Jesse James (back)

Prognosis: Another tight end injury: James has a back contusion after going high for a Ben Roethlisberger pass and taking a hard fall Saturday. Coach Mike Tomlin doesn't know the severity of the injury. Steelers starting tight end Vance McDonald has missed the entire preseason with a foot issue and Xavier Grimble underwent surgery to repair a ligament in his right thumb/wrist area. The Steelers could have all three -- or none -- for Week 1. -- Jeremy Fowler

New York Giants

Tight end Evan Engram (concussion)

Prognosis: Engram suffered a concussion in the second quarter Friday when he was sandwiched by a pair of Jets after catching a pass. He looked woozy walking off the field and into the locker room, and now has 16 days to get healthy for the opener against the Jaguars. -- Jordan Raanan

Denver Broncos

Safety Shamarko Thomas (eye)

Prognosis: Thomas was taken to a local hospital after suffering an eye injury in the first half of Friday night's game. He was being evaluated for a possible detached retina and will undergo additional tests when the team returns to Denver. -- Jeff Legwold

Detroit Lions

Tight end Luke Willson (knee)

Prognosis: Willson suffered a knee injury Friday against Tampa Bay and was ruled out for the game, according to reports. It's worth monitoring over the next week or so. -- Michael Rothstein

Carolina Panthers

Right tackle Jeremiah Sirles (hamstring)

Prognosis: Sirles left in Friday's first half and didn't return. Hamstring injuries can linger for weeks, and the Panthers already have lost three starting offensive linemen to injuries: right tackle Daryl Williams (knee, patella), left guard Amini Silatolu (torn meniscus) and left tackle Matt Kalil (knee). Fortunately, none is expected to be long-term, with the possible exception of Williams. -- David Newton

Green Bay Packers

Running back Ty Montgomery (foot)

Prognosis: Montgomery left Friday's first half with a foot injury. He was able to walk to the locker room without assistance, but he did not return.

Linebacker Oren Burks (shoulder)

Prognosis: Burks, the Packers' third-round pick, sustained a shoulder injury during pregame warm-ups. He was scheduled to start at inside linebacker but did not play. -- Rob Demovsky

Cincinnati Bengals

LT Cordy Glenn (shoulder)

Prognosis: Glenn exited Sunday's game in the second quarter with a right-shoulder injury, although he didn't leave and watched the game from the sidelines. If Glenn misses time, that's troubling for an offensive line that struggled badly at the tackle position last season. Coach Marvin Lewis said after the game that Glenn was fine. -- Katherine Terrell

Dallas Cowboys

S Kavon Frazier (shoulder)

Prognosis: Likely without projected starter Xavier Woods for the season opener because of a hamstring injury, the Cowboys lost Frazier in the first quarter Sunday against the Arizona Cardinals because of a left-shoulder injury, leaving them even thinner at the safety position. Frazier, who has also been dealing with a knee injury, did not return, forcing the Cowboys to use undrafted free agent Tyree Robinson with the first team. The Cowboys added two safeties (Jeron Johnson and Dominick Sanders) last week, but they have yet to make a play for the big prize, Earl Thomas, as he continues to sit out of Seattle Seahawks training camp. -- Todd Archer