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Betting takeaways from ESPN's Week 16 NFL Power Rankings: Here come the Colts

The Colts have had plenty of reasons to celebrate lately. Michael Allio/Icon Sportswire

Ugh. COVID-19's latest wave of destruction has made wagering on the NFL (or any other sport) an even more difficult endeavor than normal.

Closing line value is usually the main objective when making a wager. Is that still the case when so much information -- in terms of which players can even play -- is unknown mere hours before kickoff?

Regardless, all we can do is take a look at the latest Power Rankings and see what stands out.