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San Francisco 49ers 2023 betting lines, odds, schedule ATS

Christian McCaffrey and the San Francisco 49ers look to reach the NFC Championship game for the third-straight year. Photo by Ezra Shaw/Getty Images

Check out how the San Francisco 49ers fared in 2022 and forecast 2023 betting trends. The 49ers reached the NFC Championship Game for the second consecutive year but failed to make the Super Bowl. Now with Jimmy Garoppolo gone and question marks at quarterback, San Francisco looks to hold on to its momentum this season. Dig into the 2023 schedule against the spread as well as significant roster changes, thoughts on futures and more. For information on all 32 teams, click here for our complete NFL betting review and 2023 previews. 2022 betting data and 2023 betting lines are courtesy of Caesars Sportsbook.

49ers 2022 season in review

2022 win total: 10.5
2022 team record: 13-4
2022 record ATS: 11-6-0 (5th)
2022 team overs*: 9-8-0 (T-6th)

Did you know? The 49ers were 10-0 outright and 9-1 ATS as home favorites last season including the playoffs, the best record in the NFL. In Kyle Shanahan's first five seasons before last year, the 49ers were just 13-13 outright and 8-16-2 ATS as home favorites.

49ers look-ahead to 2023

2023 win total: 10.5
Odds to make the playoffs? -460 (2nd)
Odds to win Super Bowl: +850 (T-3rd)

What has changed on the 49ers' roster since last season?

Key draft picks:

• S Ji'Ayir Brown
• K Jake Moody
• TE Cameron Latu

Key additions:

• DT Javon Hargrave
• QB Sam Darnold
• G Jon Feliciano
• DE Clelin Ferrell
• CB Myles Hartsfield
• CB Isaiah Oliver

Key departures:

• QB Jimmy Garoppolo
• FS Jimmie Ward
• DE Samson Ebukam
• CB Emmanuel Moseley
• RT Mike McGlinchey
• LB Azeez Al-Shaair
• DT Hassan Ridgeway
• T Daniel Brunskill
• S Tarvarius Moore

Favorite futures for 2023

Under 10.5 wins (+140)

Quarterback is the most important position in sports, and we still don't know who will be under center for the 49ers. Trey Lance has only four starts over the past three years and is not NFL ready, Brock Purdy is coming off elbow surgery and the 49ers are Sam Darnold's third team. Defensively, I expect some regression with the loss of DC DeMeco Ryans, weakness in their interior defensive line and at slot corner.

However, I am excited to see Christian McCaffrey shine for a full season in Kyle Shanahan's system. McCaffrey put up over 1,000 yards from scrimmage from Week 8 to 18 and had 58% of the running back carries and a 20% target share. -- Anita Marks

*Record against the "over" line set for the game. Both teams are credited with a win if the game went over, a loss if under, and a tie if pushed.